Breast lesions examined by digital angiography. Work in progress.

Ackerman, L V; Watt, A C; Shetty, P.C.; Flynn, Michael J.; Burke, Matthew; Kambouris, Angelos A.; Fine, Gerald; Wilderman, S.J.

doi:10.1148/radiology.155.1.3883425

Cited by 29 publications

(9 citation statements)

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“…4,5 In the mid 1980s, Watt and Ackerman performed digital subtraction angiography ͑DSA͒ of the breast using an x-ray image intensifier system. [7][8][9] Benign and malignant lesions were differentiated according to the strength of enhancement or blush observed. Subtracted images of malignant lesions showed a rapid and strong increase in iodine content followed by a washout and benign lesions showed much less or no enhancement.…”

Section: Introductionmentioning

confidence: 99%

“…Subtracted images of malignant lesions showed a rapid and strong increase in iodine content followed by a washout and benign lesions showed much less or no enhancement. [7][8][9] Recently, considerable attention has been focused on contrast-enhanced magnetic resonance imaging of the breast using the gadolinium based contrast agent, Gd-DTPA. Several studies have shown that breast lesions can be characterized with high accuracy using MRI.…”

Section: Introductionmentioning

confidence: 99%

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Development of contrast digital mammography

et al. 2002

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Development of breast tumors is often accompanied by angiogenesis--the formation of new blood vessels. It is possible to image the effects of this process by tracking the uptake and washout of contrast agents in the vicinity of a lesion. In this article, a method for carrying out contrast subtraction mammography on a full-field digital mammography unit is described. Spectral measurements and modeling were performed to optimize the choice of x-ray target, kilovoltage and x-ray beam filtration for contrast digital mammography (CDM) on an available digital mammography system. Phantom studies were carried out to determine the sensitivity of CDM to iodine. Detection of iodine area densities of 0.3 mg/cm2 is possible for a circular object with a radius of 1.3 mm, which allows detection of uptake levels in the breast typically seen with cancer and some benign breast conditions. It was found that with a molybdenum anode x-ray tube, copper filtration could be used to effectively shape the x-ray spectrum to maximize the proportion of x rays with energies above the k edge of iodine. Simple logarithmic subtraction was found to be adequate in suppressing background signals dependent on the x-ray beam intensity and background thickness of the breast. The total x-ray dose from the procedure ranges between 1 and 3 mGy, similar to that from a conventional single view film mammogram. A clinical pilot study is currently being carried out to evaluate this technique.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of contrast digital mammography

et al. 2002

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“…Therefore, imaging methods with contrast medium potentially can aid in the detection and diagnosis of cancer. 10 In the mid-1980s, Watt et al 12 , Ackerma et al 13 , and Watt et al 14 performed digital subtraction angiography (DSA) of the breast by using and x-ray imaging intensifier system. Benign and malignant lesions were differentiated according to the strength of enhancement.…”

Section: Dual Energy Contrast Enhanced Digital Mammography (De Cedm)mentioning

confidence: 99%

Mammography: From Past to Present

Mekasut¹

2011

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“…Watt et al (16,17) and Ackerman et al (18) performed digital subtraction angiography of the breast, using an x-ray image intensifier in a conventional angiography system. They were able to demonstrate that benign and malignant lesions could be differentiated according to the strength of enhancement (referred to as "blush").…”

Section: Temporal Subtraction Angiographymentioning

confidence: 99%

X-Ray Polarization Imaging

Maidment¹

2006

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. (From -To) REPORT DATE (DD-MM-YYYY) 01-06-2006 REPORT TYPE Final DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of Pennsylvania Philadelphia, PA 19175 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES-original document contains color ABSTRACTConventional mammography evaluates the spatial arrangement of tissue in the breast; the recorded signal is determined by the x-ray attenuation of the materials in each projection. Due to the low x-ray energy, every x-ray attenuated by the breast is absorbed by the breast (i.e., all of the x-ray energy is deposited in the breast). We have investigated whether it is possible to produce breast images based on x-ray polarization. Polarization radiography appeared to have the potential to supplement mammographic images by imaging the ability of breast tissue to rotate the x-ray polarization vector. We had hoped that new information about the breast could be gleaned at a low dose to the breast; preference being given to x-rays which would pass through the breast and have altered polarization, rather than being absorbed by the breast). We performed fundamental experiments regarding x-ray polarization to determine whether the polarization effect was sufficiently large to allow it to be used to produce images. Two different x-ray polarimeters were developed and tested. We were able to demonstrate polarization of the incident x-ray beam. However, neither polarimeter allowed successful measurement of polarization alterations of any material. We did, however, develop an excellent model of x-ray spectra, which has already seen wide usage. SUBJECT TERMS Conclusions……………………………………………………………………………………………………………29 References………………………………………………………………………………………………………………30 Appendices………………………………………………………………………………………………………………32Page 4 IntroductionAt optical energies, the pol...

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Breast lesions examined by digital angiography. Work in progress.

Cited by 29 publications

References 0 publications

Development of contrast digital mammography

Development of contrast digital mammography

Mammography: From Past to Present

X-Ray Polarization Imaging

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