2007
DOI: 10.1148/radiol.2443061588
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Breast Lesions: Imaging with Contrast-enhanced Subharmonic US—Initial Experience

Abstract: SHI appears to improve the diagnosis of breast cancer relative to conventional US and mammography, albeit on the basis of results in a very limited number of subjects.

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Cited by 85 publications
(89 citation statements)
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“…For the contrast studies, Definity was administered via a peripheral vein, typically the antecubital vein, through a 20-gauge catheter/needle. Contrast agent dosage was selected based on previous imaging experience by our group for each of the contrast modes [15], [30]. The 3-D HI volume acquisition was started simultaneously with the start of bolus administration of the UCA (0.25 mL followed by 10 mL saline flush) and continued until sufficient washout of UCA was observed (typically around 60 s).…”
Section: Methodsmentioning
confidence: 99%
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“…For the contrast studies, Definity was administered via a peripheral vein, typically the antecubital vein, through a 20-gauge catheter/needle. Contrast agent dosage was selected based on previous imaging experience by our group for each of the contrast modes [15], [30]. The 3-D HI volume acquisition was started simultaneously with the start of bolus administration of the UCA (0.25 mL followed by 10 mL saline flush) and continued until sufficient washout of UCA was observed (typically around 60 s).…”
Section: Methodsmentioning
confidence: 99%
“…Imaging at this frequency (i.e., f 0 /2) therefore allows for improved UCA signal-to-tissue ratios by providing near complete tissue suppression. Our group as well as others have validated the feasibility of SHI [15], [21]- [27]. Threedimensional imaging can visualize whole lesion volumes, which in turn may provide a more accurate representation of the vascular morphology required to characterize breast lesions [28].…”
Section: Introductionmentioning
confidence: 98%
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“…B-scan ultrasonography is in the same category, although its performance can be improved using microbubble contrast agents [183] and ultrasonic colour Doppler imaging can be helpful [184]. Where malignancy is suspected, biopsy is usually needed to obtain a definitive diagnosis.…”
Section: Applications In Clinical Specialtiesmentioning
confidence: 99%
“…This results in the potential to produce higher contrast-to-tissue rations (CTR). Reports have described the feasibility and implementation of SHI [6][7][8]. To improve the subharmonic generation from UCAs the knowledge about the description of acoustic properties of Manuscript received April 16, 2012; revised May 9, 2012.…”
Section: Introductionmentioning
confidence: 99%