Breast Milk as a Possible Route of Vertical Transmission of Dengue Virus?

Barthel, Anne; Gourinat, Ann-Claire; Cazorla, C.; Joubert, C.; Dupont‐Rouzeyrol, Myrielle; Descloux, Élodie

doi:10.1093/cid/cit227

Cited by 91 publications

(84 citation statements)

References 9 publications

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“…The finding that RT-PCR on Newborn 2's serum was positive the day following the start of breast feeding can reasonably exclude this route of contamination for this infant. The ZIKV RNA load reported in the two breast milk samples (2.9 × 10 4 and 205 × 10 4 copies /mL) were higher than the DENV RNA load reported in a suspected case of DENV breast milk transmission (>0.01 × 10 4 and >0.1 × 10 4 copies /mL) in New Caledonia in 2012 [14]. Of interest, CHIKV RNA was not detected from 20 milk samples collected from breastfeeding viraemic mothers during an outbreak of CHIKV infection in Réunion Island in 2005-06 [16].…”

Section: Discussionmentioning

confidence: 59%

“…Perinatal transmission of arbovirus has been reported for DENV [10][11][12][13][14], chikungunya virus (CHIKV) [15,16], West Nile virus (WNV) [17,18] and yellow fever virus (YFV) [19,20]. Breast milk transmission has been reported for DENV [14] and WNV [18] and has been suspected for the vaccine strain of YFV [20].…”

Section: Discussionmentioning

confidence: 99%

“…Breast milk transmission has been reported for DENV [14] and WNV [18] and has been suspected for the vaccine strain of YFV [20]. Severe consequences of arbovirus materno-fetal transmission have been reported, notably for CHIKV (encephalopathy and haemorrhagic fever) [16] and DENV (preterm delivery, fetal death, low birth weight, fetal anomalies, prematurity and acute fetal distress during labour) [10,12].…”

Section: Discussionmentioning

confidence: 99%

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Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014

et al. 2014

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A Zika virus (ZIKAV) outbreak started in October 2013 in French Polynesia, South Pacific. We describe here the clinical and laboratory features of two mothers and their newborns who had ZIKAV infection as confirmed by ZIKAV RT-PCR performed on serum collected within four days post-delivery in date. The infants' infection most probably occurred by transplacental transmission or during delivery. Attention should be paid to ZIKAV-infected pregnant women and their newborns, as data on the impact on them are limited.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014

et al. 2014

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“…Transmission of ZIKV via breastfeeding has not yet been observed [8], although the transmission of other flaviviruses via this route has been described previously [54,55]. The other suspected routes of ZIKV transmission include monkey bite, mucocutaneous exposure, organ transplantation or hemodialysis [56,57].…”

Section: Transmissionmentioning

confidence: 99%

Zika virus disease: a current review of the literature

et al. 2016

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“…The CDC examined blood donations in Puerto Rico between April 3 and June 11, 2016, using a nucleic acid test and found that 68/12,777 (0.5%) samples were positive for ZIKV. 29 Other flaviviruses such as dengue and West Nile viruses can be detected in breast milk, [30][31][32] and while there is evidence for the presence of ZIKV in breast milk, there is no clear evidence for transmission. During the 2013 outbreak in French Polynesia, 2 women gave birth to It is likely that ZIKV can be transmitted through blood transfusion, although the frequency of this remains unknown.…”

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confidence: 99%

Zika virus disease for neurologists

et al. 2016

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Purpose of review: Zika virus (ZIKV) was not initially thought to be an important cause of neurologic disease, but with the recent epidemic in the Western Hemisphere, there is a growing body of evidence for possible neurologic complications. This review discusses these in addition to what is known about modes of transmission, testing for the virus, as well as future directions. Recent findings: ZIKV disease has been associated with microcephaly and congenital eye disease in infants, as well as with Guillain-Barré syndrome, uveitis, myelitis, and meningoencephalitis in adults. Summary: Even though most infections are asymptomatic, there are important possible neurologic complications of ZIKV disease in both children and adults of which neurologists should be aware.Neurol Clin Pract 2016;6:515-522 Z ika virus (ZIKV) is an RNA virus of the family Flaviviridae in the genus Flavivirus. It received its name from the Zika Forest in Uganda. In 1947, researchers placed sentinel monkeys on elevated forest platforms to study the natural transmission of yellow fever virus. ZIKV was first isolated from one of these monkeys and subsequently from a pool of Zika Forest-dwelling Aedes africanus mosquitoes. 1,2 ZIKV was first studied in animals, and was shown to be neurotropic after serial brain passage in mice.3 Interestingly, injection of ZIKV into other animals, including cotton rats, guinea pigs, and rabbits, did not cause disease.3 Monkeys were shown to develop asymptomatic infection after subcutaneous inoculation with the mouse brain-passaged virus, but even after intracerebral inoculation, only 1 of 5 monkeys developed fever, and none more extensive illness. 3There was early suggestion that ZIKV could infect humans as serosurveys in Africa showed that 6% of 99 sera samples were positive for ZIKV-specific neutralizing antibodies.3 However, ZIKV was not considered to be an important cause of human disease, as only 14 cases of symptomatic human ZIKV infection were documented between 1947 and 2006. [4][5][6][7][8]

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Breast Milk as a Possible Route of Vertical Transmission of Dengue Virus?

Cited by 91 publications

References 9 publications

Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014

Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014

Zika virus disease: a current review of the literature

Zika virus disease for neurologists

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