Breast Tissue Restoration after the Partial Mastectomy Using Polycaprolactone Scaffold

Jwa, Seung Jun; Won, Jongmin; Kim, Dohyun; Kim, Ki-Bum; Lee, Jung Bok; Heo, Min; Shim, Kyu-Sik; Jo, Han-Saem; Lee, Won Jai; Roh, Tai-Suk; Baek, Wooyeol

doi:10.3390/polym14183817

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…They were able to grow clinically relevant volumes of soft tissue over a long-term period, validating their model for tissue regeneration strategies. More recently, Jwa et al (2022) printed spherical 3D PCL scaffolds. They produced and implanted in rats three types of PCL scaffolds: 1) only PCL, 2) PCL and collagen, and 3) PCL with rat breast tissue fragment.…”

Section: Breast Tissue Scaffoldsmentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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Female breast cancer was the most prevalent cancer worldwide in 2020, according to the Global Cancer Observatory. As a prophylactic measure or as a treatment, mastectomy and lumpectomy are often performed at women. Following these surgeries, women normally do a breast reconstruction to minimize the impact on their physical appearance and, hence, on their mental health, associated with self-image issues. Nowadays, breast reconstruction is based on autologous tissues or implants, which both have disadvantages, such as volume loss over time or capsular contracture, respectively. Tissue engineering and regenerative medicine can bring better solutions and overcome these current limitations. Even though more knowledge needs to be acquired, the combination of biomaterial scaffolds and autologous cells appears to be a promising approach for breast reconstruction. With the growth and improvement of additive manufacturing, three dimensional (3D) printing has been demonstrating a lot of potential to produce complex scaffolds with high resolution. Natural and synthetic materials have been studied in this context and seeded mainly with adipose derived stem cells (ADSCs) since they have a high capability of differentiation. The scaffold must mimic the environment of the extracellular matrix (ECM) of the native tissue, being a structural support for cells to adhere, proliferate and migrate. Hydrogels (e.g., gelatin, alginate, collagen, and fibrin) have been a biomaterial widely studied for this purpose since their matrix resembles the natural ECM of the native tissues. A powerful tool that can be used in parallel with experimental techniques is finite element (FE) modeling, which can aid the measurement of mechanical properties of either breast tissues or scaffolds. FE models may help in the simulation of the whole breast or scaffold under different conditions, predicting what might happen in real life. Therefore, this review gives an overall summary concerning the human breast, specifically its mechanical properties using experimental and FE analysis, and the tissue engineering approaches to regenerate this particular tissue, along with FE models.

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Section: Breast Tissue Scaffoldsmentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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“…The platform is further lowered after one layer is finished, and the subsequent layer is then deposited. Layer thickness or height, printing speed, infill rate, nozzle temperature, retraction, shell thickness, and the potential inclusion of supports (structures that assist deposited materials in being correctly printed in cases of steep angles) are major factors that significantly affect the material’s final qualities [ 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. A schematic of a fused deposition modeling (FDM) 3D printer is shown in Figure 2 .…”

Section: 3d Bioprinting Techniquesmentioning

confidence: 99%

3D Printing in Regenerative Medicine: Technologies and Resources Utilized

Kantaros

2022

IJMS

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Over the past ten years, the use of additive manufacturing techniques, also known as “3D printing,” has steadily increased in a variety of scientific fields. There are a number of inherent advantages to these fabrication methods over conventional manufacturing due to the way that they work, which is based on the layer-by-layer material-deposition principle. These benefits include the accurate attribution of complex, pre-designed shapes, as well as the use of a variety of innovative raw materials. Its main advantage is the ability to fabricate custom shapes with an interior lattice network connecting them and a porous surface that traditional manufacturing techniques cannot adequately attribute. Such structures are being used for direct implantation into the human body in the biomedical field in areas such as bio-printing, where this potential is being heavily utilized. The fabricated items must be made of biomaterials with the proper mechanical properties, as well as biomaterials that exhibit characteristics such as biocompatibility, bioresorbability, and biodegradability, in order to meet the strict requirements that such procedures impose. The most significant biomaterials used in these techniques are listed in this work, but their advantages and disadvantages are also discussed in relation to the aforementioned properties that are crucial to their use.

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“…The low acquisition cost and shear-thinning properties of this material make it well-suited for use in medical devices and its thermal stability makes it a desirable choice for medical applications. Published literature works suggest that PCL can be used to fabricate a tissue-engineered scaffold to be used as a restoration substrate of breast tissue after a partial mastectomy operation (Jwa et al, 2022). Other reported literature cases indicate the use of PCL material combined with sodium Mesoglycan (MSG) which exhibited high rates in targeted wound healing (Liparoti et 2022) and the design and bioprinting of a novel wound-dressing material by incorporating Juglone (5-hydroxy-1,4naphthoquinone) to a 25% Polycaprolactone (PCL) scaffold (Ayran et al, 2022).…”

Section: Poly (Caprolactone)mentioning

confidence: 99%

Bio-Inspired Materials: Exhibited Characteristics and Integration Degree in Bio-Printing Operations

Kantaros¹

2022

American Journal of Engineering and Applied Sciences

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In the last decade, additive manufacturing techniques, commonly known under the term "3d printing" have seen constantly increasing use in various scientific fields. The nature of these fabrication techniques that operate under a layer-by-layer material deposition principle features several de facto advantages, compared to traditional manufacturing techniques. These advantages range from the precise attribution of pre-designed complex shapes to the use of a variety of materials as raw materials in the process. However, its major strong point is the ability to fabricate custom shapes with interconnected lattices, and porous interiors that traditional manufacturing techniques cannot properly attribute. This potential is being largely exploited in the biomedical field in sectors like bio-printing, where such structures are being used for direct implantation into the human body. To meet the strict requirements that such procedures dictate, the fabricated items need to be made out of biomaterials exhibiting properties like biocompatibility, bioresorbability, biodegradability, and appropriate mechanical properties. This review aims not only to list the most important biomaterials used in these techniques but also to bring up their pros and cons in meeting the aforementioned characteristics that are vital in their use.

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Breast Tissue Restoration after the Partial Mastectomy Using Polycaprolactone Scaffold

Cited by 8 publications

References 24 publications

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

3D Printing in Regenerative Medicine: Technologies and Resources Utilized

Bio-Inspired Materials: Exhibited Characteristics and Integration Degree in Bio-Printing Operations

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