Breastfeeding and Reduced Risk of Breast Cancer: A Systematic Review and Meta-Analysis

Abstract

Background. Evidences which prove relation between breastfeeding women and risk of breast cancer have been limited. Objective. A meta-analysis was carried out on the basis of published literature from clinical trials and studies among different parts of the world. Methods. Studies were analyzed and extracted using PRISMA flowchart. RevMan 5.4.1 was used for analyzing the extracted data. Included studies were fully cited texts with complete information about studies, trails conducted for risk of breast cancer, and breastfeeding correlations. Results. Menarche age, family history, lactation duration, and menopausal status have a strong effect on the risks of breast cancer. Family history studies concluded that for 95% CI, the risk ratio was 2.66 (2.00, 3.52). Conclusion. Findings have suggested that family history and lactation duration affect the risks of breast cancer.

Predictive Model for the Diagnosis of Benign/Malignant Complex Cystic and Solid Breast Nodules

“…The results of the present study are consistent with the finding that age is an independent risk factor for malignant nodules. Some studies showed that a history of breastfeeding reduces the likelihood of breast cancer, which is inconsistent with the results obtained in this study, and the phenomenon could be attributed to the and uneven age distribution of participants [28]. The US features, such as microcalcifications, nodule morphology, margins, and other variables that did not enter the equation, were highly suspected of malignant nodules, which might be attributed to phenomena of complex cystic nodules, BF, cystic fluid transmission, longitudinal diameter, and age.…”

Abscess-like postpartum metaplastic breast carcinoma in breastfeeding woman: a case report

“…6 Therefore, age at diagnosis, parity status and breastfeeding history are important risk factors for breast cancer. 7,8 PPBC is associated with worse survival rates presenting two-to threefold increased risk of death in both ER+ and ER-disease. 6,9,10 Interestingly, studies have shown that diagnosis during pregnancy is not associated with poorer outcomes.…”

Estrogens and the risk of breast cancer: A narrative review of literature

“…The mechanism behind this protection that the longer duration of breastfeeding provides is due to the breast cells differentiating after pregnancy to be able to lactate which decreases its responsiveness to substances like estrogen that can stimulate breast cells to become cancerous. Another way is the mechanical flushing of carcinogens and exfoliated DNA-damaged cells and insulin through breast milk, which reduces insulin levels in the blood and prevents the anti-apoptosis effects that insulin can have by increasing the level of substances like insulin-like growth factor [ 123 ]. Nevertheless, a recent review proposed there was still an unclarity of the definitive relationship between breastfeeding and breast cancer risk [ 124 ].…”