Breastfeeding with maternal antiretroviral therapy or formula feeding to prevent HIV postnatal mother-to-child transmission in Rwanda

Abstract

: Maternal HAART while breastfeeding could be a promising alternative strategy in resource-limited countries.

Prevención de la transmisión materno-infantil del virus de inmunodeficiencia humana de tipo 1 en Uruguay: 1987-2009. Análisis de las diferentes medidas adoptadas

“…Actualmente algunas investigaciones han demostrado que junto al uso materno de anti-retrovirales (ARV) el amamantamiento sería posible. Desde un enfoque de riesgo, en países donde la morbi-mortalidad infantil en ausencia de lecha materna es elevada, es aconsejable preservar la lactancia natural 11,12 . En 1994 Connors y cols., demostraron que el tratamiento con zidovudina (ZDV) a la mujer durante el www.sochinf.cl…”

11.0 References

“…WHO guidance remains that in countries where formula feeding is safe, a national or regional policy decision should be made on feeding policy [300]. Although breastfeeding transmission is reduced by ART, it is not abolished [78,293,[295][296][297]301,302]. There is laboratory evidence that the breast milk of HIV-positive women on ART contains cells that may shed virus [303].…”

“…Recently, cohort [293][294][295][296] and RCT [66,78,297] data from Africa have shown that ART can significantly reduce the risk of HIV transmission from breastfeeding. This is in settings where breastfeeding is not affordable, feasible, acceptable, sustainable and safe, and mortality from formula feeding outweighs additional mortality from HIV transmission by breastfeeding [298,299].…”

HIV in pregnancy: an international perspective

“…[39][40][41][42][43][44][45] The estimated cumulative probability of postnatal transmission of HIV in these cohorts is 0.5-3% at 6-9 months of age. 39,[42][43][44] Breastfeeding reduces infant morbidity and mortality, protects against childhood infections and promotes child spacing. In resource-poor countries mothers often have no access to clean water or formula for safe replacement feeding.…”