Breastmilk-Derived Mesenchymal Stem Cells In Vitro Are Likely to Be Mediated Through Epithelial–Mesenchymal Transition

Kaingade, Pankaj; Somasundaram, Indumathi; Nikam, Amar; Sarang, Shabari; Patel, Jagdish

doi:10.1089/bfm.2016.0023

Cited by 9 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a comprehensive report that compared various stem cell types for their potential efficacy to sequester stroke-induced neuroinflammation, feasibility as translational clinical cell sources, safety and suitability as a transplantable material, hBmSCs have been suggested as a promising source of stem cells for treatment of a stroke-associated pathology [ 72 ]. This concept for the potential therapeutic benefit of hBmSCs is largely based on results of in vitro studies where hBmSCs were cultured and differentiated in vitro followed by identification of the growth factors that they secreted [ 73 , 74 ]. Of particular importance for stroke therapy is the ability of certain subpopulations of these differentiated cells to produce VEGF and HGF and a protocol for culturing breast milk-derived cells that increase production of these factors has been established [ 73 ].…”

Section: Potential Therapeutic Use Of Breast Milk-derived Cellsmentioning

confidence: 99%

Stem cells in human breast milk

et al. 2019

View full text Add to dashboard Cite

Recent studies have demonstrated that breast milk contains a population of cells displaying many of the properties typical of stem cells. This review outlines progress made in this newly emerging field of stem cell biology and provides an analysis of the available data on purification, propagation and differentiation of certain types of progenitor cells from breast milk. The possible fates of breast milk cells, including microchimerism caused by their transmission to the distant organs of the infant, are also discussed. Unique properties of breast milk-derived stem cells, such as their unusually low tumorigenic potential and their negligible ability to form teratomas, are highlighted as obvious advantages for using these cells in regenerative therapy.

show abstract

Section: Potential Therapeutic Use Of Breast Milk-derived Cellsmentioning

confidence: 99%

Stem cells in human breast milk

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Growth factors are also secreted by breast milk stem cells (180). In fact, the concept for the potential therapeutic benefit of human milk stem cells (HMSCs) is largely based on the results of studies where HMSCs were cultured and differentiated in vitro followed by identification of the growth factors that they secreted (291,292). For example, of particular importance for stroke therapy is the ability of certain subpopulations of these differentiated cells to produce VEGF and HGF and a protocol for culturing breast milk-derived cells that increase the production of these factors, which has been established (293).…”

Section: Multi-organ Damagementioning

confidence: 99%

Anti-Infective, Anti-Inflammatory, and Immunomodulatory Properties of Breast Milk Factors for the Protection of Infants in the Pandemic From COVID-19

Quitadamo

Comegna

Cristalli

2021

Front. Public Health

View full text Add to dashboard Cite

COVID-19 pandemic since the end of 2019 spreads worldwide, counting millions of victims. The viral invasion, systemic inflammation, and consequent organ failure are the gravest features of coronavirus disease 2019 (COVID-19), and they are associated with a high mortality rate. The aim of this study is to evaluate the role of breast milk in the COVID-19 pandemic, analyzing its antiviral, anti-inflammatory, and immunoregulatory effects due to its bioactive components, so numerous and important for the protection of infants. The study tried to demonstrate that all the components of human milk are capable of performing functions on all the pathogenic events recognized and described in COVID-19 disease. Those human milk factors are well-tolerated and practically free of side effects, so breast milk should become a research topic to discover therapies even in this epidemic. In the first part, the mechanisms of protection and defense of the breast milk elements will be delineated; in the second section, it will describe the human milk effects in viral infections and it will be hypothesized how the known mechanisms could act in COVID infection.

show abstract

“…Грудное молоко формирует защиту сосудов и способствует развитию детского сердца, поскольку содержит семейство факторов роста [3,4], включая эпидермальный фактор роста (EGF), фактор роста сосудистого эндотелия (VEGF), фактор роста гепатоцитов (HGF), инсулиноподобные факторы роста [5,6], которые, действуя через аутокринные или паракринные механизмы, инициируют клеточный рост, становление дифференцированной функции. Установлено, что фактор роста гепатоцитов (HGF) способствует дифференцировке стволовых клеток сердца [7].…”

unclassified

“…Epidermal growth factor (EGF), в изобилии определяющийся в молоке кормящих матерей независимо от продолжительности беременности, имеет более высокую концентрацию в переходном грудном молоке женщин, родивших детей с очень низкой и экстремально низкой массой тела по сравнению с женщинами, родившими доношенных детей [8]. Фактор роста сосудистого эндотелия особенно важен и полезен для ранних стадий васкулогенеза и ангиогенеза у недоношенных детей [5,9], что весьма существенно, поскольку изменения васкулогенеза и ангиогенеза, выявленные у недоношенных детей еще в эмбриональной жизни, продолжаются и в зрелом возрасте [10].…”

unclassified

“…Мезенхимальные стволовые клетки по современным представлениям являются важнейшей популяцией стволовых клеток организма, принимающих непосредственное участие в физиологическом обновлении и регенерации тканей в течение всей жизни человека. В настоящий момент аналоги мезенхимальных стволовых клеток, впервые выделенных из костного мозга, обнаружены и во всех тканях, включая грудное молоко [5,23,[26][27][28].…”

unclassified

See 1 more Smart Citation