Breath analysis by ion mobility spectrometry allows to discriminate COPD from lung cancer patients

Janssens, Eline; Lamote, Kevin; Meerbeeck, Jan Van; Brusselmans, Lisa

doi:10.1183/13993003.congress-2018.pa1759

Cited by 6 publications

(5 citation statements)

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“…Volatile organic compounds (VOCs) have the potential to mirror various metabolic processes both locally within the respiratory system and systemically, via blood circulation [6,7]. VOCs have been utilised as diagnostic, prognostic and treatment response biomarkers for various respiratory illness, including infections [8][9][10][11][12]. The rapid, cost effective and non-invasive nature make VOCs a strong candidate as a potential COVID-19 biomarkers, substantiated by preliminary studies highlighting its diagnostic potential [13,14].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of COVID-19 by exhaled breath analysis using gas chromatography–mass spectrometry

et al. 2021

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BackgroundThe ongoing COVID-19 pandemic has claimed over two and a half million lives worldwide so far. SARS-CoV-2 infection is perceived to be seasonally recurrent and a rapid non-invasive biomarker to accurately diagnose patients early-on in their disease course will be necessary to meet the operational demands for COVID-19 control in the coming years.ObjectiveTo evaluate the role of exhaled breath volatile biomarkers in identifying patients with suspected or confirmed COVID-19 infection, based on their underlying PCR status and clinical probability.MethodsA prospective, real-world, observational study recruiting adult patients with suspected or confirmed COVID-19 infection. Breath samples were collected using a standard breath collection bag, modified with appropriate filters to comply with local infection control recommendations and samples were analysed using gas chromatography-mass spectrometry (TD-GC-MS).Findings81 patients were recruited between April 29th to July 10th, 2020, of whom 52/81 (64%) tested positive for COVID-19 by RT-PCR. A regression analysis identified a set of seven exhaled breath features (benzaldehyde, 1-propanol, 3, 6-methylundecane, camphene, beta-cubebene, Iodobenzene, and an unidentified compound) that separated PCR positive patients with an area under the curve (AUC): 0.836, sensitivity: 68%, specificity: 85%.ConclusionsGC-MS detected exhaled breath biomarkers were able to identify PCR positive COVID-19 patients. External replication of these compounds is warranted to validate these results.

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Section: Introductionmentioning

confidence: 99%

Diagnosis of COVID-19 by exhaled breath analysis using gas chromatography–mass spectrometry

et al. 2021

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“…Real-time analysis of exogenous volatiles contained in breath is particularly suited for pharmacokinetic studies. There are a number of real-time highly sensitive soft chemical ionization mass spectrometric methods to determine the endogenous and exogenous volatile compounds contained in a person's breath, including proton transfer reaction mass spectrometry (PTR-MS) [1][2][3][4][5], selected ion flow tube-mass spectrometry (SIFT-MS) [6,7], electrospray ionization-mass spectrometry (ESI-MS) [8,9], and ion mobility spectrometry (IMS) [10][11][12]. These techniques are particularly ideal for breath-to-breath analysis and pharmacokinetic breath studies [13].…”

Section: Introductionmentioning

confidence: 99%

Proton transfer reaction time-of-flight mass spectrometric measurements of volatile compounds contained in peppermint oil capsules of relevance to real-time pharmacokinetic breath studies

et al. 2019

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With the growing interest in the use of breath volatiles in the health sciences, the lack of standardization for the sampling and analysis of exhaled breath is becoming a major issue leading to an absence of conformity, reproducibility and reliability in spectrometric measurements. Through the creation of a worldwide ‘peppermint consortium’, the International Association of Breath Research has set up a task force to deal with this problem. Pharmacokinetic studies are proposed, and a real-time analytical technique that is being used is proton transfer reaction-time-of-flight-mass spectrometry (PTR-ToF-MS). This paper presents details on how the volatile compounds contained in a peppermint oil capsule, and hence on breath, appear in a PTR-ToF-MS. To aid that study, the key volatiles in the headspace of peppermint oil were first identified using gas chromatography-mass spectrometry, notably: menthol, menthone, 1,8-cineole, menthofuran, limonene, α-pinene and β-pinene. A PTR-ToF-MS analysis of these compounds has been undertaken, divorced from the complexity of the peppermint oil matrix using ‘normal’ and ‘saturated’ humidity drift-tube conditions, with the latter used to mimic breath samples, and over a range of reduced electric fields. There are no characteristic product ions that can distinguish monoterpenes and 1,8-cineole, and hence, without pre-separation, a combined washout for these volatiles can only be provided. By operating the drift tube above about 130 Td, there are characteristic product ions for menthone, menthofuran and menthol, namely m/z 155.14 (protonated menthone), m/z 151.11 (protonated menthofuran), m/z 139.15 (loss of H2O from protonated menthol) and m/z 83.09 (a fragment ion, C6H11 +, from menthol). These have been used to monitor, with a high specificity, the temporal profile of these three compounds in breath following the ingestion of a peppermint oil capsule. To aid in the analyses, the proton affinities and gas-phase basicities for the key volatiles investigated have been determined using density functional theory.

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“…109 In 2018, several studies were presented or published on this topic and are also summarized in Table 2. 101,105,[110][111][112][113][114][115][116][117] With the exception of one study (de Vries et al 110 ), they all included patients with a suspicion of or proven lung cancer. The percentage of patients with early-stage disease varied between 12% and 79%.…”

Section: Breath-based Screeningmentioning

confidence: 99%

“…The percentage of patients with early-stage disease varied between 12% and 79%. 101,105,[111][112][113][114][115][116][117] In the study that included patients without a suspicion of lung cancer, exhaled breathprints were collected from 639 patients with COPD who were managed according to standard care and the incidence of lung cancer was monitored at 1 year after sampling. The study showed a sensitivity of 80% and a specificity of 90% for lung cancer prediction.…”

Section: Breath-based Screeningmentioning

confidence: 99%

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

Balata

Fong

Hendriks

et al. 2019

Journal of Thoracic Oncology

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Lung cancer remains the leading cause of cancer-related mortality worldwide. Tobacco consumption remains the most important risk factor. Although the prevalence of smoking has decreased overall, it continues to be a significant burden for global health. It is estimated that there are still nearly 1 billion cigarette smokers worldwide. Prevention strategies have largely focused on tobacco control and prevention. However, we have witnessed a dramatic increase in the use of e-cigarettes and other vaping products. Primary chemoprevention has historically not been a successful strategy for lung cancer; however, focused approaches in specific groups of patients at high risk for development of lung cancer are underway. The majority of cases with NSCLC are diagnosed with locally advanced or metastatic disease, where the overall prognosis remains very poor. Early-stage NSCLC on the other hand has a much better prognosis and can usually be treated radically with either surgical resection or radical radiotherapy, with relatively favorable long-term outcomes. In addition to image-based screening, other methods such as breath-based and biofluidbased approaches are now being investigated for early detection of NSCLC. This review will focus on recent advancements in the field of prevention, screening, and early detection of NSCLC.

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Breath analysis by ion mobility spectrometry allows to discriminate COPD from lung cancer patients

Cited by 6 publications

References 0 publications

Diagnosis of COVID-19 by exhaled breath analysis using gas chromatography–mass spectrometry

Diagnosis of COVID-19 by exhaled breath analysis using gas chromatography–mass spectrometry

Proton transfer reaction time-of-flight mass spectrometric measurements of volatile compounds contained in peppermint oil capsules of relevance to real-time pharmacokinetic breath studies

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

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