Brewing complications: the effect of acute ethanol exposure on wound healing

Radek, Katherine A.; Ranzer, Matthew J.; DiPietro, Luisa A.

doi:10.1189/jlb.0209103

Cited by 28 publications

(26 citation statements)

References 103 publications

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“…For instance, it is estimated that for every youth homicide there are around 20–40 victims of non‐fatal youth violence requiring medical treatment [2]. Additionally, there is evidence that acute alcohol intoxication prior to injury significantly reduces the likelihood of a positive outcome following medical treatment [3].…”

Section: Introductionmentioning

confidence: 99%

A review of emergency room studies on alcohol and injuries conducted in Latin America and the Caribbean region

Andreuccetti¹,

Carvalho²,

Korcha³

et al. 2012

Drug and Alcohol Review

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Issues Alcohol-attributable burden of injury is one of the most serious public health problems in Latin America and the Caribbean region (LAC). Although knowledge on alcohol’s involvement in injuries has progressed along with the implementation of evidenced-based alcohol policies in developed countries, this was not true for the most part of LAC countries for which reducing alcohol-related injuries is an urgent necessity. Approach A systematic review was performed in order to identify the most up-to-date information on alcohol and injuries derived from emergency room (ER) studies conducted in LAC. Key Findings Findings corroborate that alcohol has a high prevalence among injured patients in the ER setting in LAC, with violence-related injuries showing an increased association with alcohol use compared to unintentional injuries. However, a large number of studies did not include all types of injury and the measurement of injury risk associated with alcohol consumption. The amount of alcohol consumed in the event and hazardous drinking patterns seem to be strongly associated with injury occurrence, as well as drinking in public spaces, but a paucity of data relating to social-contextual factors limits the interpretation of the heterogeneity in the magnitude of the association of alcohol and injuries found across studies. Conclusions There is a lack of ER studies able to support strategies to reduce alcohol-related injuries in a region where effective alcohol policies are scant. Future research should focus on understanding how drinking influenced by local contexts and drinking behaviors may affect the risk of injury within each LAC country.

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Section: Introductionmentioning

confidence: 99%

A review of emergency room studies on alcohol and injuries conducted in Latin America and the Caribbean region

Andreuccetti¹,

Carvalho²,

Korcha³

et al. 2012

Drug and Alcohol Review

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“…Tissue recovery becomes even more difficult when these two factors are associated [31,43]. Most studies included in this systematic review reported wound healing impairments following a high-fat diet and alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models

et al. 2017

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Background and purposeChronic alcohol intake associated with an inappropriate diet can cause lesions in multiple organs and tissues and complicate the tissue repair process. In a systematic review, we analyzed the relevance of alcohol and high fat consumption to cutaneous and repair, compared the main methodologies used and the most important parameters tested. Preclinical investigations with murine models were assessed to analyze whether the current evidence support clinical trials.MethodsThe studies were selected from MEDLINE/PubMed and Scopus databases, according to Fig 1. All 15 identified articles had their data extracted. The reporting bias was investigated according to the ARRIVE (Animal Research: Reporting of in Vivo Experiments) strategy.ResultsIn general, animals offered a high-fat diet and alcohol showed decreased cutaneous wound closure, delayed skin contraction, chronic inflammation and incomplete re-epithelialization.ConclusionIn further studies, standardized experimental design is needed to establish comparable study groups and advance the overall knowledge background, facilitating data translatability from animal models to human clinical conditions.

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“…L‐12‐LOX was used here for the enzymatic synthesis of 14 S ‐HDHA and 14 S ,21‐diHDHA. AE is known to greatly reduces leukocyte infiltration to wounds or inflammation sites as well as leukocyte activation [Radek et al, 2009], which may significantly contribute to the reduction of 14 S ‐hydroxy‐generating L‐12‐LOX‐like activity. P‐12‐LOX also has the14 S ‐hydroxy‐generating activity [Kim et al, 1990].…”

Section: Discussionmentioning

confidence: 99%

Novel 14S,21‐dihydroxy‐docosahexaenoic acid rescues wound healing and associated angiogenesis impaired by acute ethanol intoxication/exposure

Tian

Lü

Shah

et al. 2010

J of Cellular Biochemistry

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Acute ethanol intoxication and exposure (AE) has been known to impair wound healing and associated angiogenesis. Here we found that AE diminished the formation of novel reparative lipid mediator 14S,21-dihydroxy-docosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid (14S,21-diHDHA) and its biosynthetic intermediate 14S-hydroxy-DHA (14S-HDHA) from docosahexaenoic acid (DHA) in murine wounds. However, AE did not reduce the formation of DHA and the intermediate 21-HDHA. These results indicate that in the biosynthetic pathways of 14S,21-diHDHA in wounds, AE suppresses the 14S-hydroxy-generating activity of 12-lipoxygenase-like (LOX-like), but does not suppress the 21-hydroxy-generating activity of cytochrome P450 and DHA-generating activities. The AE-suppression of 12-LOX-like activity was further confirmed by the diminished formation of 12-hydroxy-eicosatetraenoic acid in wounds under AE. Supplementing 14S,21-diHDHA to wounds rescued the AE-impaired healing and vascularization. 14S,21-diHDHA restored AE-impaired processes of angiogenesis in vitro: endothelial cell migration, tubulogenesis, and phosphorylation of p38 mitogen-activated protein kinase (MAPK). Taken together, the suppression of 14S,21-diHDHA formation is responsible, at least partially, for the AE-impairment of cutaneous wound healing and angiogenesis. Supplementing 14S,21-diHDHA to compensate its deficit in AE-impaired wounds rescues the healing and angiogenesis. These results provide a novel mechanistic insight for AE-impaired wound healing that involves the necessary roles of 14S,21-diHDHA. They also offer leads for developing 14S,21-diHDHA-related therapeutics to ameliorate AE-impairment of wound healing.

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Brewing complications: the effect of acute ethanol exposure on wound healing

Cited by 28 publications

References 103 publications

A review of emergency room studies on alcohol and injuries conducted in Latin America and the Caribbean region

A review of emergency room studies on alcohol and injuries conducted in Latin America and the Caribbean region

Effect of a high-fat diet and alcohol on cutaneous repair: A systematic review of murine experimental models

Novel 14S,21‐dihydroxy‐docosahexaenoic acid rescues wound healing and associated angiogenesis impaired by acute ethanol intoxication/exposure

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