This study aims to investigate the effect of Socio Scientific Issues (SSI) approach in the science learning to enhance students' scientific literacy. 90 students of 8th graders, who were divided into three classes, were involved. They learned by using the same SSI approach but with the different themes, including global warming, food additives, and living thingenvironment interaction. After the learning process, students performed the literacy test related to the topics. The results showed that the SSI approach in science learning made students feel the need to learn science, and makes learning more meaningful. In addition, the students' scientific literacy increased in the high category after the implementation. All three aspects of competency, including explaining scientific phenomena, interpreting data and scientific evidence, and evaluating data and facts scientifically, showed a high increase. The similar increase was also shown in knowledge aspects. On the other hand, the enhancement of attitude toward science aspect showed lower category in average.