Brief Communication

O’Carroll, Ronan E.; Conway, S. C.; Ryman, Ann; Prentice, Neil

doi:10.1017/s0033291796004679

Cited by 18 publications

(3 citation statements)

References 15 publications

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“…Of nine delayed memory measures in six studies, five measures met the recommended cutoff for sensitivity, including Delayed Word Recall (O'Carroll et al 1997) for AD versus Depression and the NAB Daily Memory Delayed Recall (Gavett et al 2012) for AD versus “non-AD” group, as well as RBANS – List Recall (McDermott and DeFilippis 2010), RBANS – Delayed Memory Index (McDermott and DeFilippis 2010) and delayed figure recall for AD versus VaD (Matioli and Caramelli 2010). Only two of the nine tasks met the recommended cutoff for specificity, including an Enhanced Cued Recall task (Esen Saka and Elibol 2009) for AD versus PD, and the NAB Daily Living Memory – Delayed Recall (Gavett et al 2012) for AD versus “non-AD.”…”

Section: Resultsmentioning

confidence: 99%

“…Three measures of recognition were included and all met the recommended cutoff of 80%(Consensus Workgroup 1998) for sensitivity, including Delayed Word Recognition (O'Carroll et al 1997) for AD versus depression, RBANS-List Recognition (McDermott and DeFilippis 2010) for AD versus VaD, and CERAD or Auditory Verbal Learning Test (AVLT) List Recognition (Schmidtke and Hüll 2002) for AD versus small vessel disease. However, importantly, the specificity of recognition measures was low (ranging from 47 to 66%), for AD versus depression and VaD.…”

Section: Resultsmentioning

confidence: 99%

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Diagnostic Accuracy of Memory Measures in Alzheimer’s Dementia and Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

et al. 2017

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With an increasing focus on biomarkers in dementia research, illustrating the role of neuropsychological assessment in detecting mild cognitive impairment (MCI) and Alzheimer’s dementia (AD) is important. This systematic review and meta-analysis, conducted in accordance with PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) standards, summarizes the sensitivity and specificity of memory measures in individuals with MCI and AD. Both meta-analytic and qualitative examination of AD versus healthy control (HC) studies (n = 47) revealed generally high sensitivity and specificity (≥ 80% for AD comparisons) for measures of immediate (sensitivity = 87%, specificity = 88%) and delayed memory (sensitivity = 89%, specificity = 89%), especially those involving word-list recall. Examination of MCI versus HC studies (n = 38) revealed generally lower diagnostic accuracy for both immediate (sensitivity = 72%, specificity = 81%) and delayed memory (sensitivity = 75%, specificity = 81%). Measures that differentiated AD from other conditions (n = 10 studies) yielded mixed results, with generally high sensitivity in the context of low or variable specificity. Results confirm that memory measures have high diagnostic accuracy for identification of AD, are promising but require further refinement for identification of MCI, and provide support for ongoing investigation of neuropsychological assessment as a cognitive biomarker of preclinical AD. Emphasizing diagnostic test accuracy statistics over null hypothesis testing in future studies will promote the ongoing use of neuropsychological tests as Alzheimer’s disease research and clinical criteria increasingly rely upon cerebrospinal fluid (CSF) and neuroimaging biomarkers.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Diagnostic Accuracy of Memory Measures in Alzheimer’s Dementia and Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

et al. 2017

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“…However, patients with severe depression also tend to perform poorly on both verbal and nonverbal memory tests [ 8 - 10 ]. To complicate matters even further, difficult verbal episodic memory tasks such as recall tasks often fail to discriminate accurately severe depression patients from mild AD patients [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Differential diagnosis of depression and Alzheimer’s disease with the Addenbrooke's Cognitive Examination-Revised (ACE-R)

et al. 2015

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BackgroundOne of the usual problems psychologists and clinicians face in clinical practice is differential diagnostics of Alzheimer’s disease and depression. It has been reported that the ACE and ACE-R could discriminate the cognitive dysfunctions due to depression from that due to dementia, although this is not uniform in all studies. The current study aimed to evaluate the utility of the ACE-R to differentiate late-life onset depression (with severe episode) from mild-moderate Alzheimer’s Disease (AD).MethodsThis study received approval from the Lithuanian Bioethics Committee. All participants were older than 50 years (mean age = 66.52 (±8.76) years). The study sample consisted of 295 individuals: 117 with severe depression, 85 with mild-moderate Alzheimer’s disease (AD), and 94 age, gender and education matched participants of control group.ResultsThe ACE-R had high sensitivity (100%) and specificity (81%) at detecting cognitive impairments related to AD. Patients with late-life onset depression (ACE-R mean 76.82, SD = 7.36) performed worse than controls (ACE-R mean 85.08, SD = 7.2), but better than the AD group (ACE-R mean 54.74, SD = 12.19). Participants with late-life onset depression were differentiated by mild impairment in the ACE-R total score with mild memory (13.79, SD = 6.29) and greater deficits in letter fluency (3.65, SD = 1.21) than in semantic fluency (4.68, SD = 1.23). Participants with AD were differentiated by severely impaired performance on attention and orientation (11.80, SD = 2.93), memory (8.25, SD = 3.47) and language subtests (17.21, SD = 4.04), and moderately impaired performance on verbal fluency (6.07, SD = 2.74).ConclusionsACE-R has diagnostic accuracy in detecting people with AD and can be used in differential diagnostics of late-life onset depression (severe episode) and AD. Diagnostic accuracy may be improved by analyzing the neuropsychological profiles and using lower cutoffs for different age groups.

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Alzheimer's disease, depression and normal ageing: merit of simple psychomotor and visuospatial tasks

Hofman

Seifritz

Kräuchi

et al. 2000

Int J Geriat Psychiatry

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Brief Communication

Abstract: We conclude that the DWR is not specific enough to clearly distinguish patients with early Alzheimer's disease from elderly patients with major depression.

Cited by 18 publications

References 15 publications

Diagnostic Accuracy of Memory Measures in Alzheimer’s Dementia and Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

Diagnostic Accuracy of Memory Measures in Alzheimer’s Dementia and Mild Cognitive Impairment: a Systematic Review and Meta-Analysis

Differential diagnosis of depression and Alzheimer’s disease with the Addenbrooke's Cognitive Examination-Revised (ACE-R)

Alzheimer's disease, depression and normal ageing: merit of simple psychomotor and visuospatial tasks

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