Brief Communication

Baselmans, A.H.C.; Kuijpers, M.H.M.; Dijk, J. E. van

doi:10.1177/019262339602400313

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…Histopathologically, the mast cell tumors described in the two case reports originated in the thymus and in the eyelid, and they were reportedly characterized by sheet-like proliferation of the round cells and fine eosinophilic granules in the cytoplasm. However, infiltration of eosinophils and an increase in collagen fibers were not observed, unlike in cases of these tumors in dogs and cats 1 , 2 , 3 , 4 . This report describes the histological characteristics of a spontaneous malignant mast cell tumor with thymic epithelial hyperplasia in a male Royal College of Surgeons (RCS) rat.…”

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confidence: 63%

“…Mast cell tumors are common skin neoplasms in dogs and cats 3 , 4 , where they are generally composed of round cells with eosinophilic and basophilic granules yielding metachromasia. With regard to rodents, chemical- and radiation-induced mast cell tumors, as well as spontaneous mast cell tumors, have been reported in mice 8 , 9 , 10 , 11 , 12 ; however, to our knowledge, mast cell tumors are very rare in rats: only two case reports and 12 NTP pathology database entries exist for rat mast cell tumors 1 , 2 . The mast cell tumors in the two previous case reports originated in the thymus and in the eyelid and were characterized by sheet-like proliferation of the round cells as well as by the presence of fine eosinophilic granules in the cytoplasm.…”

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confidence: 93%

“…Mast cell tumors are extremely rare in rats: rat mast cell tumors have only been reported in two case reports and 12 cases in National Toxicology Program (NTP) pathology database entries 1 , 2 . Histopathologically, the mast cell tumors described in the two case reports originated in the thymus and in the eyelid, and they were reportedly characterized by sheet-like proliferation of the round cells and fine eosinophilic granules in the cytoplasm.…”

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confidence: 99%

“…Granular cell tumors and globule leukocyte tumors are characterized as round cell tumors with eosinophilic granules, similar to those observed in the current case. Accordingly, metachromasia, using toluidine blue, was required to confirm the diagnosis 1 , 2 , 13 , 14 .…”

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Malignant mast cell tumor of the thymus in an Royal College of Surgeons (RCS) rat

2017

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A 152-week-old male Royal College of Surgeons (RCS) rat kept as a non-treated animal in a long-term animal study presented with a soft mass in the anterior mediastinum, which adhered to the pleura of the lung. Histopathologically, the mass mainly consisted of round to short spindle-shaped tumor cells that had infiltrated through the hyperplastic thymic tissue. The tumor cells were arranged in loose to dense sheets. Nuclei were moderate in size and round to spindle-shaped, with small nucleoli. Almost all tumor cells exhibited abundant eosinophilic cytoplasm, including eosinophilic granules of a range of sizes. The granules of tumor cells exhibited metachromasia with toluidine blue stain and were positive for c-kit and mast cell protease II. These findings indicate that the tumor described here represents a rare case of spontaneous malignant mast cell tumor with thymic epithelial hyperplasia.

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confidence: 63%

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confidence: 93%

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confidence: 99%

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confidence: 99%

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Malignant mast cell tumor of the thymus in an Royal College of Surgeons (RCS) rat

2017

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“…This tumor also exhibited inflammatory cell infiltration in the neoplastic foci or nodules. Polymorphic features accompanied by lymphocytes and eosinophils have been observed in mastocytosis and mast cell sarcoma 17 , 20 . The granules of mast cells are known to contain chemotactic mediators that facilitate eosinophilic infiltration or other inflammatory changes and play a central role in type 1 hypersensitivity 8 .…”

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Spontaneous globule leukocyte tumor accompanied by inflammatory cells in a Wistar Hannover rat

Sato¹,

Tomonari²,

Doi³

et al. 2019

J Toxicol Pathol

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We encountered hematolymphoid neoplastic lesions in the form of many nodules in the spleen and liver in a 110-week-old male Wistar Hannover rat (Crl:WI (Han)). The lesions contained atypical proliferative cells, eosinophils, lymphocytes, and macrophages. The proliferative cells comprised various atypical cell types with or without cytoplasmic eosinophilic granules. The granules were positively stained using periodic acid-Schiff and elastase stains, were bluish purple using phosphotungstic acid and hematoxylin, and showed no metachromasia using toluidine blue. In immunohistochemical staining, the proliferative cells with or without granules were positive for granzyme B, rat mast cell protease II, and Ki67. Electron microscopic examination revealed that single to multiple high-density granules of variable size were covered by a membrane. These findings led to a diagnosis of globule leukocyte tumor. The accompaniment of this tumor by inflammatory cells is likely evoked by mast cell-like active mediators contained in the granules of the globule leukocytes.

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Rats

2017

Pathology of Small Mammal Pets

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Brief Communication

Cited by 9 publications

References 14 publications

Malignant mast cell tumor of the thymus in an Royal College of Surgeons (RCS) rat

Malignant mast cell tumor of the thymus in an Royal College of Surgeons (RCS) rat

Spontaneous globule leukocyte tumor accompanied by inflammatory cells in a Wistar Hannover rat

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