Brief, high-frequency stimulation of the corticomedial amygdala induces a delayed and prolonged increase of aggressiveness in male Syrian golden hamsters.

Potegal, Michael; Hebert, Mark; DeCoster, Mark A.; Meyerhoff, James L.

doi:10.1037/0735-7044.110.2.401

Cited by 55 publications

(23 citation statements)

References 80 publications

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“…expression in DOM and SUB males above an initial response to handling. The MeA has been implicated in a variety of behavioral responses [e.g., mating (Lehman et al, 1980;Lehman and Winans, 1982;Kollack-Walker and Newman, 1995), aggression (Shibata et al, 1982;L uiten et al, 1985;Kollack-Walker and Newman, 1995;Potegal et al, 1996b), and affiliative behavior (Kirkpatrick et al, 1994)], and induction of c-fos mRNA after fighting is consistent with a role of this brain region in behavioral arousal (De Jonge et al, 1992;Kollack-Walker and Newman, 1995;Potegal et al, 1996b) and social memory (Bolhuis et al, 1984;Vochteloo and Koolhaas, 1987). The SON showed the greatest increase in DOM males.…”

Section: Acute Exposure To Intermale Aggressionmentioning

confidence: 60%

Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain

1997

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During an agonistic encounter, subordinate male hamsters display defensive and submissive postures and show increased secretion of glucocorticoids, whereas dominant males do not. To determine whether specific neuronal pathways are activated during the behavioral and neuroendocrine responses of subordinate males, expression of c-fos mRNA within the brains of subordinate males was compared with the pattern in dominant males after fighting. After 1 week of handling, pairs of hamsters were either swapped between cages (handled control males), or were allowed to interact for 30 min [dominant (DOM) males and subordinate (SUB) males]. A second group of control animals that received no handling or social stimulation (unhandled control males) were also included. After testing, all animals were killed by decapitation, their brains were removed for c-fos in situ hybridization, and trunk blood was collected for analysis of plasma cortisol and corticosterone levels. Exposure of males to their partner's cage for 30 min resulted in increased expression of c-fos mRNA in multiple brain regions. In addition, fighting increased c-fos expression in the medial amygdaloid nucleus of both DOM and SUB males as well as having more selective effects. In DOM males, c-fos expression was elevated within the supraoptic nucleus of the hypothalamus. In SUB males, c-fos expression increased within a multitude of brain areas, including cingulate cortex, lateral septum, bed nucleus of the stria terminalis, medial preoptic area, several hypothalamic nuclei, central amygdaloid nucleus, amygdalohippocampal area, dorsal periaqueductal gray, dorsal raphe, cuneiform nucleus, and locus coeruleus. These findings are discussed in relation to neurocircuits associated with behavioral arousal and stress.

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Section: Acute Exposure To Intermale Aggressionmentioning

confidence: 60%

Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain

1997

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“…In males, electrical stimulation of the area is sufficient to elicit aggressive responding by residents towards intruders [Potegal et al, 1996b]. Interestingly, the effect of electrical stimulation was correlated with enhanced c-Fos expression within the anterior parts of the MeA.…”

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confidence: 87%

“…These areas are distributed across the limbic system and include the septum, hypothalamus, amygdala and preoptic area Sodetz and Bunnell, 1970;Hammond and Rowe, 1976;Shipley and Kolb, 1977;Potegal et al, 1981aPotegal et al, , b, 1996b. For instance, offensive aggression is inhibited by electrical stimulation of the septum [Potegal et al, 1981b], whereas the behavior is activated by stimulation of the corticomedial amygdala [Potegal et al, 1996b].…”

Section: Introductionmentioning

confidence: 99%

Neural Connections of the Anterior Hypothalamus and Agonistic Behavior in Golden Hamsters

2000

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In male golden hamsters, offensive aggression is regulated by an interaction between arginine-vasopressin and serotonin at the level of the anterior hypothalamus. The present studies were conducted to study a neural network underlying this interaction. The connections of the anterior hypothalamus were examined by retrograde and anterograde tracing in adult male hamsters. Several limbic areas were found to contain both types of tracing suggesting reciprocal connections with the anterior hypothalamus. Their functional significance relating to the consummation of aggression was tested by comparing neuronal activity (examined through quantification of c-Fos-immunolabeling) in two groups of animals. Experimental animals were sacrificed after attacking an intruder. Control animals were sacrificed after exposure to a woodblock carrying the odor of an intruder that elicited behaviors related to offensive aggression without its consummation. An increased density of Fos-immunoreactivity was found in experimental animals within the medial amygdaloid nucleus, ventrolateral hypothalamus, bed nucleus of the stria terminalis and dorsolateral part of the midbrain central gray. These data suggest that these areas are integrated in a neural network centered on the anterior hypothalamus and involved in the consummation of offensive aggression. Finally, c-Fos-immunoreactivity was combined with labeling of serotonin and vasopressin neurons to identify sub-populations particularly associated with offensive aggression. Vasopressin neurons in the nucleus circularis and medial division of the supraoptic nucleus showed increased neuronal activity in the fighters, supporting their role in the control of offensive aggression.

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“…Anger and rage reactions, mediated by the lateral AM in the presence of a sexual rival or intruder, set up a long-lasting state of "aggressive arousal" which changes the probability and time course of ongoing aggressive behaviour (Potegal, Hebert, DeCoster, & Meyerhoff, 1996). However, because the AM also learns who is a rival and who is not, the regulatory impact of aggressive arousal on behaviour is sure to change with experience.…”

Section: Development Of Amygdala-mediated Self-regulationmentioning

confidence: 99%

The self-regulating brain: Cortical-subcortical feedback and the development of intelligent action

Lewis

Todd

2007

Cognitive Development

149

118

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To speak of cognitive regulation versus emotion regulation may be misleading. However, some forms of regulation are carried out by executive processes, subject to voluntary control, while others are carried out by "automatic" processes that are far more primitive. Both sets of processes are in constant interaction, and that interaction gives rise to a stream of activity that is both cognitive and emotional. Studying the brain helps us understand these reciprocal regulatory influences in some detail. Cortical activities regulate subcortical activities through executive modulation of prepotent appraisals and emotional responses. Subcortical systems regulate the cortex by tuning its activities to the demands or opportunities provided by the environment. Cortical controls buy us time, as needed for planning and intelligent action. Subcortical controls provide energy, focus, and direction, as needed for relevant emotion-guided behaviour. We review the neural processes at work in both directions of regulatory activity, looking at the anterior cingulate cortex (ACC) as a hub of cortical systems mediating downward control, and discussing limbic, hypothalamic, and brainstem systems that mediate upward control. A macrosystem that displays both directions of control includes the ACC and the amygdala within a feedback circuit whose features vary with clinical-personality differences. Developmental changes in ACC-mediated self-regulation support advances in directed attention, response inhibition, and self-monitoring. Developmental changes in amygdala-mediated self-regulation involve the compilation of meanings that direct thought and behaviour, thus consolidating individual differences over the lifespan. In this way, the capacity to exert voluntary control develops alongside the accumulation of associations that trigger the responses that demand control. The balance between these developmental progressions has implications for personality formation and mental health.

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Brief, high-frequency stimulation of the corticomedial amygdala induces a delayed and prolonged increase of aggressiveness in male Syrian golden hamsters.

Cited by 55 publications

References 80 publications

Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain

Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain

Neural Connections of the Anterior Hypothalamus and Agonistic Behavior in Golden Hamsters

The self-regulating brain: Cortical-subcortical feedback and the development of intelligent action

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