Brief report: Biological factors associated with asperger syndrome

Rickarby, Geoffrey A.; Carruthers, Anne; Mitchell, Margery

doi:10.1007/bf02207330

Cited by 20 publications

(6 citation statements)

References 10 publications

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“…Obstetric abnormalities were present in eight out of 10 patients with AS; this high figure is consistent with the study of Rickarby et al (1991), which found that seven out of a sample of 10 children with AS had a history of obstetric abnormalities. Obstetric insults sustained by our sample of AS patients appear to be milder qualitatively compared to those reported by Wing (1981) and Gillberg (1989).…”

Section: Discussionsupporting

confidence: 89%

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Obstetric factors in Asperger syndrome: comparison with high‐functioning autism

Ghaziuddin¹,

Shakal²,

Tsai³

1995

J intellect Disabil Res

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Asperger syndrome (AS) is a pervasive developmental disorder widely regarded as a mild variant of autism. To investigate if AS is associated with a history of fewer obstetric insults compared to autism, we examined the developmental history and obstetric records of 10 males with AS (mean full scale IQ 95.3), and compared them with 10 autistic males with a full scale IQ of 70 or above (so-called high-functioning autism; mean full scale IQ 82.6). Males with AS showed a trend toward lower Apgar scores at one minute (chi-square = 4; df = 1; P = 0.04) and were more likely to have been born to mothers outside the optimal age group of 20-30 years (chi-square = 5; df = 1; P = 0.02). They were also less likely to have been irritable and floppy as infants (chi-square = 3.8; df = 1; P = 0.05). However, the total optimality scores did not differ significantly between the two groups.

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Section: Discussionsupporting

confidence: 89%

“…None of the studies cited above used the ICD-Io criteria of AS since, with the exception of the study of Rickarby et al (1991), these were published before the ICD-IO (1990). This is important because patients with mental retardation and speech delay are excluded from the ICD-IO definition of AS.…”

Section: Introductionmentioning

confidence: 99%

Obstetric factors in Asperger syndrome: comparison with high‐functioning autism

Ghaziuddin¹,

Shakal²,

Tsai³

1995

J intellect Disabil Res

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“…If a person exhibits symptoms similar to these then he/she may have AS, although there were arguments over whether AS is a disability at all. The Simon Baron‐Cohen article 13 suggests that these symptoms may just be differences, while others argue that they are a result of neurological differences 21 …”

Section: Resultsmentioning

confidence: 99%

Examining online chat within a domain of uncertainty: the case of Asperger's syndrome

Lorence¹

2007

Health Info Libraries J

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Objective : To determine whether grounded theory can be applied as a crossdisciplinary evaluative framework for assessing health information, especially within domain-specific peer-to-peer networks. Methods : Using a grounded-theory approach, we seek to identify recurring themes of peer-based interaction, without the ongoing management of clinical experts, as a way to determine stakeholder concerns and interests in a domain of frequent clinical uncertainty and treatment, Asperger's syndrome. Results : We find that users of web-based information in such areas often report reliance on information for medical decision making and disease management, at times to the point where interaction becomes a form of 'cybertherapy.' Further, such groups often evolve into disease-specific, 'virtual support groups', even where discussions highlight a lack of consensus regarding the role, function and quality of information within this unique domain. Conclusion : A grounded theory approach can successfully be applied in a domain-specific setting to identify themes in unstructured peer-to-peer discussion of ill-defined diseases and treatments.

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“…However, the empirical data on the etiology and pathogenesis of AS is scant, and much of current clinical consensus derives from inferences drawn from the study of autistic disorder. The few studies that have been published (e.g., Ghaziuddin, Shakal, & Tsai, 1995;Gillberg, 1989;Rickarby, Carruthers, & Mitchell, 1991) have been on samples of no more than one or two dozen individuals. However, recently, a genome-wide-scan for susceptibility genetic loci was performed by a Finnish group, finding at least two loci (on chromosomes 1 and 3) that have previously been identified as susceptibility loci for autistic disorder (Ylisaukko-oja et al, 2004).…”

Section: Introductionmentioning

confidence: 98%