BRIEF REPORT: Defective Synthesis of IgM Antibodies in Macroglobulinemia

Pitts, Neal C.; McDuffie, Frederic C.

doi:10.1182/blood.v30.6.767.767

Cited by 7 publications

(1 citation statement)

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“…In patients with malignant paraproteinemia the with low paraprotein levels (1,9,14,22). high incidence of bacterial infections has been Another point of interest is whether the polyascribed to a defective antibody response, as clonal immunoglobulin levels, which can be shown by the response to test antigens (2, 6, low or in the low normal range in these pa- 8,12,15,16). In patients with asymptomatic tients (1,3,9), reflect the humoral immune paraproteinemia data about the susceptibility to capacity.…”

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confidence: 99%

Immune Response in Asymptomatic Paraproteinemia

et al. 1976

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In a group of 20 patients with asymptomatic paraproteinemia, as judged after at least 3 years of follow‐up, the primary and secondary antibody response to Helix pomatia hemocyanin (HPH) was defective as compared with the response in controls. The class of antibody was assessed by mercaptoethanol (ME) treatment of serum. A lowered response was found not only in the total but also in the ME‐resistant (mainly 7S, IgG) antibody titer. Low anti‐HPH antibody titers were preferentially found in the patients with high serum paraprotein levels, whereas in half of the patients with low serum paraprotein levels a completely normal antibody response was found. No differences in the total or 7S anti‐HPH antibody response were found between patients with IgG, IgM, or IgA paraproteinemia. The polyclonal serum Ig levels were not predictive for the measured anti‐HPH response. The anamnestic diphtheria and tetanus antibody response was not different from that of controls.

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confidence: 99%

Immune Response in Asymptomatic Paraproteinemia

et al. 1976

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Immunoglobulin m deficiency in the immune response of patients with rheumatoid arthritis

Bandilla¹,

Pitts²,

McDuffie³

1970

Arthritis & Rheumatism

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The specific antibody production in patients with rheumatoid arthritis in response to three antigen-heep cell stroma, Brucellin and Limulus polyphemus hemocyanin-was examined. Several antigens were used in expectation that an abnormality in antibody production might be selective and not uniform for all , antigens. Patients with rheumatoid arthritis were deficient in their IgM response to sheep cell stroma and Brucellin, especially the latter. This deficiency was limited to the primary response and to secondary responses characterized by only slight increases in antibody levels. More intensive stimulation resulted in equal production of IgM antibody in both groups. Antigenic competition may explain the deficiency in IgM antibody production. Levels of rheumatoid factor increased after repeated stimulation paralleling, in general, the specific antibody responses.The presence of rheumatoid factor (RF), an IgM antibody reacting with autologous and heterologous IgG (1,2) , and the frequent increase in the concentrations of immunoglobulins in patients with rheuFrom the Mayo Clinic and Mayo Foundation, Rochester, Minn and

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Immunodeficiency States Associated with Acute Leukemias, Multiple Myeloma, and Waldenström’s Macroglobulinemia

Koziner

Good

1978

The Immunopathology of Lymphoreticular Neoplasms

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BRIEF REPORT: Defective Synthesis of IgM Antibodies in Macroglobulinemia

Cited by 7 publications

References 0 publications

Immune Response in Asymptomatic Paraproteinemia

Immune Response in Asymptomatic Paraproteinemia

Immunoglobulin m deficiency in the immune response of patients with rheumatoid arthritis

Immunodeficiency States Associated with Acute Leukemias, Multiple Myeloma, and Waldenström’s Macroglobulinemia

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