Immunoglobulin m deficiency in the immune response of patients with rheumatoid arthritis

The in vitro responsiveness of peripheral blood lymphocytes to a variety of mitogens was compared in cells from normal volunteers, from patients with rheumatoid arthritis and from patients with degenerative joint disease (osteoarthritis). A consistent and marked depression in the proliferative response to Conconavalin A was noted, while statistically comparable results were obtained with PHA and allogeneic lymphocytes. The significance of these observations is discussed with particular reference to a possible discrete defect in a subpopulation of T cells in these patients.

Section: Discussionsupporting

confidence: 79%

Immunologic reactivity in rheumatoid arthritis response to mitogens

Lance

Knight

1974

“…Indeed, low titer of 7s and 19s antibodies to blood groups A and B antigens has been reported in rheumatoid arthritis (40,41). Also selective deficiency of IgM antibody production in response to a weak antigenic stimulus was observed in this disease (42). T h e concentration of immunoglobulins in rheumatoid synovial fluids vary, being either low, equal, or higher than in the corresponding sera (39).…”

Section: Discussionmentioning

confidence: 81%

Bacteriolytic and bactericidal activity of sera and synovial fluids in rheumatoid arthritis and in osteoarthritis

Pruzanski¹,

Leers²,

Wardlaw³

1974

Bacteriolytic and bactericidal activity was evaluated in sera and synovial fluids of 28 patients with rheumatoid arthritis and 13 patients with osteoarthritis. An attempt was made to correlate the results with the concentrations of the total hemolytic complement, lysozyme, immunoglobulins, transferrin, and the titer of the Latex fixation. Bacteriolytic activity in all but 5 hypocomplementemic rheumatoid sera and in all osteoarthritic sera was normal. There was a correlation (P = 0.01) between bacteriolytic activity and the level of complement, but not the level of other factors or the titer of the Latex fixation. Bacteriolytic activity in the rheumatoid and osteoarthritic synovial fluids was low, being respectively four times and two times weaker than in the corresponding sera. It correlated well only with the level of complement (P < 0.01). Bactericidal activity of rheumatoid and osteoarthritic sera was normal but was very significantly decreased in the synovial fluids, being respectively 10 times weaker and four times weaker than in the corresponding sera. The only positive correlation was found between bactericidal activity and the complement level (P < 0.01). There was no correlation between the titer of the Latex fixation and the level of the total hemolytic complement either in serum or in synovial fluids. The influence of 6 antiarthritic drugs on antibacterial activity was tested by addition of drugs to the normal human serum. There was no change in bacteriolytic activity, however bacterial growth was inhibited when high concentrations of drugs were mixed with the culture medium. infection, namely phagocyte related and antibacterial humoral activity, the former It has long been known that infection

“…Bandilla also showed that patients with RA have a deficient IgM response to active immunization with keyhole limpet hemocyanin (24). Only after intense stimulation could adequate levels of IgM antibodies be achieved (24). However, patients with SLE develop high titers of IgG isohemagglutin antibody titers in response to injections with incompatible blood group antigens (25).…”

Section: Discussionmentioning

confidence: 99%

Antibodies to dna in patients with rheumatoid arthritis and juvenile rheumatoid arthritis

Bell

Talal

Schur

1975

Antibodies to double‐stranded DNA (DSDNA) were found in 18 patients with RA, in 5 patients with JRA, and in 5 patients with undiagnosed connective tissue disease. Five patients had clinical features consistent with both RA and SLE, 11 with only RA, and 5 with only JRA. Based on these observations, the presence of serum anti‐DSDNA antibodies should not be used as a sole criterion in the diagnosis of SLE.