Brief report: If you build it, they will come

Sheppard, Vanessa B.; Cox, Lisa Sanderson; Kanamori, Mariano; Cañar, Janet; Rodriguez, Yosselyn; Goodman, Michelle; Pomeroy, Jyl; Mandelblatt, Jeanne S.; Huerta, Elmer

doi:10.1111/j.1525-1497.2005.0083.x

Cited by 49 publications

(25 citation statements)

References 15 publications

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“…7,14 Thus, developing culturally adapted videos and bilingual education websites may increase Latino’s awareness and knowledge about clinical trials. Indeed, strategies to overcome language and cultural barriers have proven to be successful in recruiting Latinas for cancer prevention and control studies 31 and for clinical trials in particular. 28,32 For instance, the Cancer Therapy and Research Center in Texas developed a strategic focus to improve Latino recruitment into clinical trial, achieving 45% Latino accrual rate in 2012.…”

Section: Discussionmentioning

confidence: 99%

Motivators and barriers to Latinas' participation in clinical trials: The role of contextual factors

London

Hurtado‐de‐Mendoza

Song

et al. 2015

Contemporary Clinical Trials

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Objective Latinas are underrepresented in clinical trials despite the rise in Hispanic population. This study examines the factors associated with Latinas’ willingness to participate in preventive breast cancer randomized clinical trials (RCTs). Methods Women self-identifying as Latina, over age 40, with no prior history of breast cancer were eligible. Using the Behavior Model for Vulnerable Populations, we administered a survey (n=168) to assess predisposing (e.g., knowledge), enabling (e.g., trust) and need factors (e.g., risk perception). Intention to participate was defined using a lenient (maybe, probably or definitely) and a stringent criterion (probably and definitely). Chi-square tests and logistic regression models examined the associations of predisposing, enabling, and need factors with women’s intentions to participate in RCTs. Results Most participants (74.9%) were monolingual Spanish-speaking immigrants. Most (83.9%) reported willing to participate in clinical trials using the lenient definition (vs. 43.1% under the stringent definition). Using the lenient definition, the odds of willing to participate in RCTs were significantly lower for unmarried women (OR=.25, 95% CI=.08–.79) and those with lower cancer risk perceptions (OR=.20, 95% CI=.06–.63), while being significantly higher for women with lower language acculturation (OR=6.2, 95% CI=1.8–20.9). Using the stringent definition, women who did not endorse a motivation to enroll to help family members (if they had cancer) had significantly lower odds to report intent (OR=.33, 95% CI=.13–.86). Conclusion Many RCTs may have limited generalizability due to the low representation of minorities. Culturally targeted interventions that address the importance of family for Latinos may ultimately increase their participation in RCTs.

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Section: Discussionmentioning

confidence: 99%

Motivators and barriers to Latinas' participation in clinical trials: The role of contextual factors

London

Hurtado‐de‐Mendoza

Song

et al. 2015

Contemporary Clinical Trials

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“…This lack of diversity in randomized study populations reduces opportunities for discovering effects that may be particularly relevant to underrepresented populations and contributes to inequitable distribution of benefits and risks of trial participation. Studies also show that individuals from medically underserved populations are more likely to be diagnosed with advanced stage diseases that might have been treated more effectively if diagnosed earlier [6]. These racial differences in access to state-of-the-art care contribute to disparities in cancer mortality and survival after cancer diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Recruitment and retention results for a population-based cervical cancer biobehavioral clinical trial

Osann

Wenzel

Doğan

et al. 2011

Gynecologic Oncology

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Background Minority and low-income cancer patients are underrepresented in clinical trials, contributing to diminished access to state-of-the-art care and disparities in cancer outcomes including survivorship issues. In cervical cancer, there is a disproportionate disease burden among minority and underserved women and persistent quality of life disruption. We encountered significant challenges in both recruitment and retention in a randomized biobehavioral clinical trial for cervical cancer survivors, identified through California Cancer Registries, leading to this investigation. Methods To determine differential rates of accrual and retention, data from our trial are analyzed using descriptive statistics, logistic regression and multivariate analysis of variance. Ethnic differences in associations between covariables and attrition rates were tested by interaction factors. Process evaluation and focus group data were obtained to inform improvement strategies. Results Of eligible subjects with viable phone numbers, 29% enrolled and 71% actively or passively refused. Enrolled Hispanic women were more likely to have less education (p<0.001), lower income (p=0.003), and more children (p=0.028). The drop out rate was associated with less education (p=0.012), foreign-birth (p=0.061), speaking Spanish in the home (p=0.012). Reported reasons for active refusal were ‘too busy’ for all women, ‘too emotional’ for non-Hispanic women, ‘too ill’ and phlebotomy for Hispanic women. Subsequent focus groups identified specific strategies to improve study materials. Conclusion Although population-based recruitment of minority and underserved cancer patients continues to be a challenge, specific sociodemographic and disease variables can predict accrual difficulties. The information herein, taken together with disease and culturally relevant strategies, can be useful when recruiting underserved cancer survivors.

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“…Identification of a spokesperson for cancer-related health messages has not been well explored but studies that have examined preferences among Hispanics for other health issues have shown varied preferences, depending on the topic [26,27,28,32]. …”

Section: Discussionmentioning

confidence: 99%

Preferences for Hereditary Breast and Ovarian Cancer Information among Mexican, Cuban and Puerto Rican Women at Risk

Quinn

McIntyre²,

Vadaparampil³

2010

Public Health Genomics

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Background: Little is known about the preferences of at-risk Hispanic women to gain information on hereditary breast and ovarian cancer (HBOC). Aims: This study sought to qualitatively explore preferences for HBOC information among at-risk Mexican, Puerto Rican and Cuban women and to pilot a mock brochure aimed at Hispanic women. Methods: Hispanic women aged 18–65 years with a personal or family history of breast or ovarian cancer participated in a semistructured interview. Data were analyzed using a combination of open-coding and content analysis. Results: Fifty-three women participated in the study. For the majority of content areas, there were no major differences between the subethnicities. All women reported discussing cancer with a doctor after a family member had been diagnosed and discussing cancer within their families; however, the content of the discussion varied. Cuban and Puerto Rican women reported using the Internet routinely for health care information while Mexican women said they did not have access to computers and did not use them. All women liked the content and photos in the brochure but Mexican women thought the reading level was too high. Preferences for the spokesperson focused on the need for Spanish-speaking health care providers. Conclusions: While the data show some similarities, such as patterns of cancer discussion and appreciation of the mock brochure, there were differences between the groups on information preferences. In designing HBOC education information for Hispanic audiences, it is important to consider varied channels for dissemination and preferences for specific types of information across subethnicities.

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Brief report: If you build it, they will come

Cited by 49 publications

References 15 publications

Motivators and barriers to Latinas' participation in clinical trials: The role of contextual factors

Motivators and barriers to Latinas' participation in clinical trials: The role of contextual factors

Recruitment and retention results for a population-based cervical cancer biobehavioral clinical trial

Preferences for Hereditary Breast and Ovarian Cancer Information among Mexican, Cuban and Puerto Rican Women at Risk

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