Brief report: Pharmacokinetics of ciprofloxacin in young (healthy volunteers) and elderly patients, and concentrations in prostatic fluid, seminal fluid, and prostatic adenoma tissue following intravenous administration

Naber, Kurt G.; Sörgel, Fritz; Kees, Frieder; Jaehde, Ulrich; Schumacher, Harald

doi:10.1016/0002-9343(89)90023-5

Cited by 38 publications

(19 citation statements)

References 2 publications

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“…Ciprofloxacin concentrations in prostatic fluid reach particularly high levels 3-10 times higher than the serum levels because ciprofloxacin molecules become trapped inside the prostatic acini. However, these results were not confirmed in two other studies reported later on by Naber et al [58,59]. In those two studies regarding ciprofloxacin concentration in prostatic fluid, these investigators found much lower concentrations than those mentioned above [55][56][57].…”

Section: Ciprofloxacinmentioning

confidence: 72%

Penetration of Antimicrobial Agents into the Prostate

et al. 2003

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In the present review article, the penetration of antimicrobial agents into prostatic fluid and tissue was examined. Three major factors determining the diffusion and concentration of antimicrobial agents in prostatic fluid and tissue are the lipid solubility, dissociation constant (pKa) and protein binding. The normal pH of human prostatic fluid is 6.5–6.7, and it increases in chronic prostatitis, ranging from 7.0 to 8.3. A greater concentration of antimicrobial agents in the prostatic fluid occurs in the presence of a pH gradient across the membrane separating plasma from prostatic fluid. Of the available antimicrobial agents, β-lactam drugs have a low pKa and poor lipid solubility, and thus penetrate poorly into prostatic fluid, expect for some cephalosporins, which achieve greater than or equal to the inhibitory concentration. Good to excellent penetration into prostatic fluid and tissue has been demonstrated with many antimicrobial agents, including tobramycin, netilmicin, tetracyclines, macrolides, quinolones, sulfonamides and nitrofurantoin.

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Section: Ciprofloxacinmentioning

confidence: 72%

Penetration of Antimicrobial Agents into the Prostate

et al. 2003

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“…Ciprofloxacin is one of the fluoroquinolones with good antimicrobial activity against most uropathogens [3,21]. However, a small number of bacteria are protected from antibiotics by an intrinsic mechanism, can stimulate a prolonged immunological reaction and evolve in response to an unfavourable environment.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effect between lycopene and ciprofloxacin on a chronic bacterial prostatitis rat model

Han

Yang

Sohn

et al. 2008

International Journal of Antimicrobial Agents

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“…To study prostatic fluid drug levels in volunteers, we [19,[26][27][28][29][30][31][32][33] developed a method to rule out or at least to indicate possible urinary contamination. The subjects were not allowed to void urine after drug intake until the prostatic fluid sample was taken.…”

Section: Prostatic Fluidmentioning

confidence: 99%