Synergistic effect between lycopene and ciprofloxacin on a chronic bacterial prostatitis rat model

Han, Chang Hee; Yang, Cho Hwan; Sohn, Dong Wahn; Kim, Sae Woong; Kang, Sung Hak; Cho, Yong-Hyun

doi:10.1016/j.ijantimicag.2007.07.016

Cited by 26 publications

(16 citation statements)

References 20 publications

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“…Recently, Han et al [42] evaluated the anti-inflammatory effects of lycopene, ciprofloxacin, or both in a chronic bacterial prostatitis rat model. After 2 weeks of treatment, microbiological culture analyses of the prostate and urine as well as a histological analysis of the prostate were conducted in order to evaluate the severity of prostatic inflammation (amount of chronic inflammatory cell infiltrates and acinar changes in interstitial fibrosis).…”

Section: Discussionmentioning

confidence: 99%

Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Category IIIA with Serenoa repens plus Selenium and Lycopene (Profluss®) versus S. repens Alone: An Italian Randomized Multicenter-Controlled Study

et al. 2010

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Objectives: To evaluate the efficacy and safety of Serenoa repens + selenium and lycopene (Profluss®) versus S. repens alone for the treatment of category IIIa chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Patients and Methods: 102 patients with IIIa CP/CPPS were enrolled and randomized into two groups each to receive Profluss or S. repens alone for 8 weeks. Evaluation was based on results of the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), IPSS, maximum peak flow rate (MPFR), and PSA measurements at baseline and at weeks 4, 8 and 8 after the end of treatment. The primary endpoint was a >50% reduction in NIH-CPSI score. Secondary endpoints evaluated were MPFR, IPSS, PSA and white blood cell count. Results: No patients withdrew from the study. The mean NIH-CPSI score decreased significantly (p < 0.001) in both groups; we observed a decrease in the total score from 27.45 to 13.27 in group 1 (–51.64%) and from 27.76 to 20.62 in group 2 (–26.06%). IPSS improved significantly (p < 0.001) in both arms, but more in group 1. PSA and white blood cell count decreased significantly (p < 0.007) only in group 1. The MPFR improved more in group 1 (p < 0.005). Conclusion: Profluss is a triple therapy that is safe and well tolerated. It ameliorates symptoms associated with IIIa CP/CPPS.

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Section: Discussionmentioning

confidence: 99%

Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Category IIIA with Serenoa repens plus Selenium and Lycopene (Profluss®) versus S. repens Alone: An Italian Randomized Multicenter-Controlled Study

et al. 2010

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“…To overcome these limitations, many studies using the CBP rat model have been currently conducted and others have reported methods to enhance the effects of antibiotics [7][8][9][10]13]. However, more research is needed to apply the results clinically, and a continuous use of antibiotics is inevitable.…”

Section: Discussionmentioning

confidence: 99%

“…Urine was collected by bladder puncture. Microbiological and histological analysis was performed at all groups as previously described [7][8][9][10].…”

Section: Methodsmentioning

confidence: 99%

Preventive effect of selenium on chronic bacterial prostatitis

Kim

Woo

et al. 2012

Journal of Infection and Chemotherapy

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“…To overcome these difficulties, many studies using the rat model of CBP have recently been conducted, and research on methods to upgrade the efficiency of antibiotics has been reported [7][8][9][10]16] . However, clinical applica- tion of these findings still requires more research, and the continuous use of antibiotics to treat CBP is currently unavoidable.…”

Section: Discussionmentioning

confidence: 99%

“…Urine was collected by cystocentesis. Microbiological and histological analyses were performed in all groups as previously described [7][8][9][10] .…”

Section: Methodsmentioning

confidence: 99%

Does Finasteride Have a Preventive Effect on Chronic Bacterial Prostatitis? Pilot Study Using an Animal Model

Lee

Ha²,

Yim³

et al. 2011

Urol Int

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Aim: To evaluate the preventive effect of finasteride on chronic bacterial prostatitis (CBP), Wistar rats were divided into four groups: control, ciprofloxacin, finasteride, and ciprofloxacin/finasteride. Methods: All drug pretreatments were conducted for 4 weeks, and then experimental CBP was induced by instillation of a bacterial suspension (Escherichia coli Z17 O2:K1;H–). Results: After 4 weeks, results of microbiological cultures of prostate and urine samples as well as histological findings of the prostate in each group were analyzed. Finasteride significantly reduced bacterial infection and decreased inflammatory cell infiltration in prostatic tissue compared with the control group. The group given both finasteride and antibiotic showed a greater inhibition of bacterial infection in the tissue than those given either finasteride or antibiotic alone. Conclusion: Our experiments suggest the possibility that finasteride has a preventive effect on development of CBP, although there is as yet no consensus on the mechanism of this effect.

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Synergistic effect between lycopene and ciprofloxacin on a chronic bacterial prostatitis rat model

Cited by 26 publications

References 20 publications

Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Category IIIA with <i>Serenoa repens</i> plus Selenium and Lycopene (Profluss®) versus <i>S. repens</i> Alone: An Italian Randomized Multicenter-Controlled Study

Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Category IIIA with <i>Serenoa repens</i> plus Selenium and Lycopene (Profluss®) versus <i>S. repens</i> Alone: An Italian Randomized Multicenter-Controlled Study

Preventive effect of selenium on chronic bacterial prostatitis

Does Finasteride Have a Preventive Effect on Chronic Bacterial Prostatitis? Pilot Study Using an Animal Model

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