A long-term assessment of the Waste Isolation Pilot Plant (WIPP) repository performance must consider the impact of gas generation resulting from the corrosion and microbial degradation of the emplaced waste. A multiphase fluid flow code, TOUGH2/EOS8, was adapted to model the processes of gas generation, disposal room creep closure, and multiphase (brine and gas) fluid flow, as well as the coupling between the three processes. System response to gas generation was simulated with a single, isolated disposal room surrounded by homogeneous halite containing two anhydrite interbeds, one above and one below the room. The interbeds were assumed to have flow connections to the room through high-permeability, excavation-induced fractures.System behavior was evaluated by tracking four performance measures: (1) peak room pressure; (2) maximum brine volume in the room; (3) total mass of gas expelled from the room; and (4) the maximum gas migration distance in an interbed. A deterministic approach, including baseline and sensitivity simulations, was used. Baseline simulations used current best estimates of system parameters, selected through an evaluation of available data, to predict system response to gas generation under best-estimate conditions. Sensitivity simulations quantified the effects of parameter uncertainty by evaluating the change in the performance measures in response to parameter variations. In the sensitivity simulations, a single parameter value was varied to its minimum and maximum values, representative of the extreme expected values, with all other parameters held at best-estimate values.Simulation results indicated that (1) in the absence of interbed fracturing, disposal room pressures will exceed, lithostatic, even at gas-generation rates representative of vapor-limited conditions, (2) under best-estimate conditions, brine availability was insufficient to fully exhaust the brine-dependent gas-generation potential, (3) the mass of gas expelled from the room and the gas migration distance are much more sensitive to the total mass of gas generated than to the gas-generation rate, and (4) the halite properties are important to gas migration because gas movement in the interbeds is limited by the displacement of interbed brine into the surrounding halite.Sensitivity simulations identified the following parameters as important to gas expulsion and migration away from a disposal room: interbed porosity; interbed permeability; gas-generation potential; halite permeability; and interbed threshold pressure. The uncertainty in multiphase flow parameters was not adequately characterized because of the lack of WIPP-specific data. Simulations also showed that the inclusion of interbed fracturing and a disturbed rock zone had a significant impact on system performance.The TOUGH2/EOS8 deterministic simulation and sensitivity results were similar to stochastic results obtained by WIPP Performance Assessment from a repository-scale model. Because the deterministic approach allows conceptual models to be quanti...