British Association of Dermatologists guidelines for the safe and effective prescribing of oral ciclosporin in dermatology 2018

Berth‐Jones, J.; Exton, L.S.; Ladoyanni, Evmorfia; Mustapa, M.F. Mohd; Tebbs, Veronica; Yesudian, Patrick; Levell, N. J.; McHenry, P.; Leslie, Tabi A.; Wakelin, S. H.; Hunasehally, R.Y.P.; Cork, Michael J.; Johnston, Graham A.R.; Chiang, N.; Worsnop, Fiona; Salim, A.; Buckley, D.A.; Petrof, Gabriela; Callachand, N.; Flavell, T.; Salad, A.A.

doi:10.1111/bjd.17587

Cited by 32 publications

(51 citation statements)

References 417 publications

(507 reference statements)

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“…In patients with TB risk factors; in contact with individuals with active TB because of travel, work, or a family relationship or patients with selected underlying medical conditions. $ (Amatore et al, 2019;Berth-Jones et al, 2019;Gisondi et al, 2017;Maiberger et al, 2017;Menter et al, 2009b;Nast et al, 2015; A. Nast et al, 2012;A.…”

Section: Pediatricmentioning

confidence: 99%

Practical compendium for psoriasis management

Ibrahim

Amer

Nofal

et al. 2020

Dermatologic Therapy

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Psoriasis management is complex and challenging. It should be tailored for each patient. Treatment strategy differs according to patient's age, sex, disease type, disease severity, burden on patient's quality of life, comorbidities, involvement of specific sites, and pregnancy. The choice of the appropriate therapeutic must take into consideration the availability, the price, and the patient's preferences. It is very important that the chosen treatment is not more unpleasant, intolerable, or dangerous than the disease itself. According to the disease type, severity, and effect on patient's quality of life, dermatologist chooses whether to start with topical therapy, phototherapy or systemic therapy, or a combination of two or more of them. Under each category, there are different types of therapies that can be the first line therapeutics, second line, or even contraindicated. In this compendium, we provide dermatologists with different treatment plans considering all the mentioned variables so that a dermatologist can choose the optimum plan for the patient.

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Section: Pediatricmentioning

confidence: 99%

Practical compendium for psoriasis management

Ibrahim

Amer

Nofal

et al. 2020

Dermatologic Therapy

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“…Initially recommended in organ transplantation, CSa has also demonstrated its effectiveness in autoimmune and immune-mediated skin conditions such as psoriasis or aD. CSa acts by suppression of the t helper cell response through inhibition of lymphocyte activation (34). the therapy should start with a dose of 2.5-5 mg/ kg/day given orally in divided doses twice daily, with dose tapering of 0.5-1 mg/kg every two weeks after achieving disease control (30).…”

Section: Systemic Therapiesmentioning

confidence: 99%

“…the therapy should start with a dose of 2.5-5 mg/ kg/day given orally in divided doses twice daily, with dose tapering of 0.5-1 mg/kg every two weeks after achieving disease control (30). treatment should not exceed a two-year continuous regimen; short courses of treatment lasting up to six months are advised (34).…”

Section: Systemic Therapiesmentioning

confidence: 99%

“…the most significant side effects are renal toxicity and hypertension; additionally, there were reported skin infections, headache, gingival hyperplasia, hypertrichosis, increased risk of skin cancer and lymphoma (29). CSa should be used with caution in combination with nSaIDs, aminoglycosides, quinolones, digoxin, statins, grapefruit juice or grapefruit (34) and should be avoided in combination with UV-therapy.…”

Section: Systemic Therapiesmentioning

confidence: 99%

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Recommended strategies for atopic dermatitis management in Romania

Ţiplica¹,

Sălăvăstru²,

Szepietowski³

et al. 2019

Ro Med J.

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Recommended stRategies foR atopic deRmatitis management in Romaniaprof. george-sorin tiplica 1 , md, phd, prof. carmen maria salavastru 2 , md, phd, prof. Jacek c. szepietowski 3 , md, phd, prof. magdalena czarnecka-operacz 4 , md, phd, assist. prof. alina suru 2 , md, phd, assist. prof. ionela manole 1 , md, phd student ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease with a relapsing course that has a significant impact on the quality of life of both patients and their families. The pathogenesis of AD is due to a multitude of factors and can be associated with other allergy-related diseases, including asthma, food allergies or rhinitis. Treatment of AD aims to reduce duration, severity, and frequency of disease exacerbations. Understanding the maintenance of skin barrier integrity by continuing the use of basic therapy can prevent breaks. Patient and family education is important.

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“…CsA is used as an adjunct to corticosteroid therapy for AA as well as in a monotherapy [7,19]. Protocols with various dosage regimens, treatment durations and corticosteroids used have been described to date [20]. The lack of unambiguous guidelines in the selection of a treatment algorithm for AA is an ongoing issue for evidence-based practitioners.…”

Section: Introductionmentioning

confidence: 99%

Cyclosporine With and Without Systemic Corticosteroids in Treatment of Alopecia Areata: A Systematic Review

Nowaczyk

Makowska

Rakowska

et al. 2020

Dermatol Ther (Heidelb)

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Introduction: Cyclosporine is commonly used in treatment for alopecia areata. It can be administered as a monotherapy or in combination with systemic corticosteroids, with various outcomes. Methods: Efficacy of cyclosporine with and without systemic corticosteroids for alopecia areata was evaluated by a systematic review. Cochrane, EBSCOhost, Pubmed, Scopus and Web of Science databases were searched. Only studies published before January 2020 were included. Results: A total of 2104 studies were initially examined, of which 14 were eligible for the systematic review. Among 340 reported cases, 213 had focal, multifocal or ophiasis form of alopecia areata, 60 were diagnosed with alopecia totalis and 67 with alopecia universalis. The mean response rate in the whole group of patients at the end of treatment was 65.00% (221/340; range 25-100%). Hair regrowth rate was higher in the group with cases of alopecia areata limited to scalp (124/165; mean 75.15%; range 40-100%) than in the cases with alopecia totalis (30/46; mean 65.22%; range 25-100%) or alopecia universalis (24/52; mean 46.15%; range 25-100%). The combined therapy with systemic corticosteroids was superior to the monotherapy (152/219; mean 69.41%; 0-80% vs. 69/121; mean 57.02%; range 6.67-100%) and had a lower recurrence rate (39/108; mean 36.11% vs. 34/46; mean 73.91%, respectively). The combined treatment with methylprednisolone was significantly more effective when compared to the cyclosporine monotherapy (124/183; mean 67.76%; range 0-80% vs. 69/121; mean 57.02%; range 6.67-100%). The mean time of treatment was 6.75 months (range 2-36). Limitations: Limitations of our study were the retrospective character of included studies, differences in doses of prescribed drugs, and duration of the treatment and follow-up times. Conclusion: Cyclosporine in combination with oral systemic corticosteroids is more effective than in monotherapy for severe alopecia areata. Key Summary PointsCyclosporine combined with systemic corticosteroids is more effective for alopecia areata than cyclosporine in monotherapy.The combined therapy allows one to reduce dose of cyclosporine.Relapses are less frequently correlated with the combined therapy.Large extend of skin involvement could be a risk factor of a negative treatment response.

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British Association of Dermatologists guidelines for the safe and effective prescribing of oral ciclosporin in dermatology 2018

Cited by 32 publications

References 417 publications

Practical compendium for psoriasis management

Practical compendium for psoriasis management

Recommended strategies for atopic dermatitis management in Romania

Cyclosporine With and Without Systemic Corticosteroids in Treatment of Alopecia Areata: A Systematic Review

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