British Committee for Standards in Haematology guidelines for aplastic anaemia: single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10<sup>9</sup>/l

Yan, Matthew; Lin, Yulia; Callum, Jeannie

doi:10.1111/bjh.14767

Br J Haematol

2017

DOI: 10.1111/bjh.14767

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British Committee for Standards in Haematology guidelines for aplastic anaemia: single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10⁹/l

Matthew Yan

Yulia Lin

Jeannie Callum

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Cited by 3 publications

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“…British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 3 10 9 /L -RESPONSE to Yan et al Yan et al (2017) report that their single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 9 10 9 /l. They reference the published British Committee for Standards in Haematology (BCSH) Guidelines for the diagnosis and management of adult aplastic anaemia (AA) patients (Killick et al, 2016).…”

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confidence: 97%

“…Yan et al () report that their single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10 9 /l. They reference the published British Committee for Standards in Haematology (BCSH) Guidelines for the diagnosis and management of adult aplastic anaemia (AA) patients (Killick et al , ).…”

mentioning

confidence: 99%

“…They reference the published British Committee for Standards in Haematology (BCSH) Guidelines for the diagnosis and management of adult aplastic anaemia (AA) patients (Killick et al , ). The recommendation in the BCSH guideline, as Yan et al () correctly state, is ‘Prior to administration of antithymocyte globulin (ATG), a daily threshold (pre‐transfusion) platelet count of 20 × 10 9 /l should be used for the duration of the ATG course’ and this is based on expert opinion only (Grade 2C). The European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party guidelines recommend patients should be transfused optimally to achieve a platelet count >30 × 10 9 /l before ATG treatment (Hochsmann et al , ).…”

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confidence: 99%

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British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10⁹/L ‐ RESPONSE to Yan et al

Killick

Bown²,

Cavenagh

et al. 2017

Br J Haematol

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confidence: 97%

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confidence: 99%

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confidence: 99%

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British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10⁹/L ‐ RESPONSE to Yan et al

Killick

Bown²,

Cavenagh

et al. 2017

Br J Haematol

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Envenoming by a captive Inland Taipan, Oxyuranus microlepidotus (McCoy, 1879), Elapidae. A case report, observations on clinical efficacy of expired antivenom and review of O. microlepidotus envenoming

Weinstein,

Keyler,

Jensen

et al. 2024

Toxicon

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Recent developments in microfluidic passive separation to enable purification of platelets for transfusion

Dinh,

Iqbal,

Abhishek

et al. 2024

Biomicrofluidics

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Platelet transfusion is a lifesaving therapy intended to prevent and treat bleeding. However, in addition to platelets, a typical unit also contains a large volume of supernatant that accumulates multiple pro-inflammatory contaminants, including residual leukocytes, microaggregates, microparticles, antibodies, and cytokines. Infusion of this supernatant is responsible for virtually all adverse reactions to platelet transfusions. Conventional methods for removing residual leukocytes (leukoreduction) and reducing the volume of transfused supernatant (volume reduction) struggle to mitigate these risks holistically. Leukoreduction filters can remove leukocytes and microaggregates but fail to reduce supernatant volume, whereas centrifugation can reduce volume, but it is ineffective against larger contaminants and damages platelets. Additionally, platelet purification based on these methods is often too logistically complex, time-consuming, and labor-intensive to implement routinely. Emerging microfluidic technologies offer promising alternatives through passive separation mechanisms that enable cell separation with minimal damage and drastically reduced instrumentation size and facility requirements. This review examines recent innovations in microfluidic cell separation that can be used for leukoreduction and volume reduction of platelets. It begins by defining the performance requirements that any separation method must meet to successfully replace conventional methods currently used to perform these tasks. Standard performance metrics are described, including leukocyte depletion efficiency, degree of volume reduction, processing throughput, and platelet recovery. Finally, the review outlines the primary challenges that must be overcome to enable simple-to-use, disposable microfluidic devices capable of both reducing the platelet unit volume and removing pro-inflammatory contaminants, while preserving most functional platelets for transfusion.

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British Committee for Standards in Haematology guidelines for aplastic anaemia: single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10⁹/l

Cited by 3 publications

References 7 publications

British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10⁹/L ‐ RESPONSE to Yan et al

British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10⁹/L ‐ RESPONSE to Yan et al

Envenoming by a captive Inland Taipan, Oxyuranus microlepidotus (McCoy, 1879), Elapidae. A case report, observations on clinical efficacy of expired antivenom and review of O. microlepidotus envenoming

Recent developments in microfluidic passive separation to enable purification of platelets for transfusion

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British Committee for Standards in Haematology guidelines for aplastic anaemia: single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 109/l

Cited by 3 publications

References 7 publications

British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 109/L ‐ RESPONSE to Yan et al

British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 109/L ‐ RESPONSE to Yan et al

Envenoming by a captive Inland Taipan, Oxyuranus microlepidotus (McCoy, 1879), Elapidae. A case report, observations on clinical efficacy of expired antivenom and review of O. microlepidotus envenoming

Recent developments in microfluidic passive separation to enable purification of platelets for transfusion

Contact Info

Product

Resources

About

British Committee for Standards in Haematology guidelines for aplastic anaemia: single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10⁹/l

British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10⁹/L ‐ RESPONSE to Yan et al

British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10⁹/L ‐ RESPONSE to Yan et al