Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice

Ferrarini, Eduarda Gomes; Paes, Rodrigo Sebben; Baldasso, Gabriela Mantovani; Assis, Pollyana Mendonça de; Gouvêa, Murilo Chaves; Cicco, Paola De; Raposo, Nádia Rezende Barbosa; Capasso, Raffaele; Moreira, Eduardo Luiz Gasnhar; Dutra, Rafael Cypriano

doi:10.1016/j.biopha.2022.113552

Cited by 80 publications

(16 citation statements)

References 31 publications

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“…From our findings, we found that SCE is highly enriched with many antioxidant compounds. A lot of polyphenolic and flavonoid compounds present in this extract such as luteolin, luteolin 7- O - β -glucoside, myricetin, and ellagic acid and triterpenoids like oleanolic acid and maslinic acid are too many important bioactive compounds which have been reported for treating numerous types of diseases like diabetes, malignancy, stroke, myalgia, anxiety, and atherosclerosis [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Kundu

Debnath

Ahad

et al. 2023

BioMed Research International

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Sonneratia caseolaris (L.) is a common mangrove plant which has significant medicinal value in traditional medicine. Ethanol extract from the fruits of S. caseolaris (SCE) was used in this project to explore its different pharmacological effects considering its traditional usage. In the castor oil-induced diarrheal method, SCE significantly lengthened the latency of the first defecation period up to 95.8 and 119.4 min as well as lowering stool count by 43.3% and 64.4% at the doses of 250 and 500 mg/kg, respectively. In evaluating the neuropharmacological effect using the open-field model, a significant central nervous system (CNS) depressant nature was observed after a reduction in the no. of squares crossed by mice at various time intervals. In evaluating the blood coagulation effect, SCE significantly reduced blood clotting time at 5.86, 5.52, and 5.01 min at 25, 50, and 100 mg/ml doses, respectively. In the assessment of the anthelmintic effect, SCE significantly killed Paramphistomum cervi (P. cervi) where the death times of the nematodes were 40.3, 36.8, and 29.9 min at 12.5, 25, and 50 mg/ml doses, respectively. The extract showed a very poor cytotoxic effect in brine shrimp lethality bioassay. In molecular docking analysis, maslinic acid, oleanolic acid, luteolin, luteolin 7-O-β-glucoside, myricetin, ellagic acid, and R-nyasol showed the best binding affinities with the selected proteins which might be the credible reasons for eliciting pharmacological responses. Among these seven compounds, only luteolin 7-O-β-glucoside had two violations in Lipinski’s rule of five.

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Section: Discussionmentioning

confidence: 99%

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Kundu

Debnath

Ahad

et al. 2023

BioMed Research International

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“…Sin embargo, el uso de cannabis y CBD en la fibromialgia no está exento de riesgos donde estudios sobre usuarios de cannabis encontraron una mayor incidencia de psicosis y esquizofrenia, así como asociada con otros trastornos psiquiátricos además se asocia con deterioro de la memoria, retrasos cognitivos y del desarrollo, particularmente en pacientes más jóvenes por lo que la selección de pacientes en las cuales se resultaron más beneficios que daños es importante (37).…”

Section: Efectos Adversos Del Cannabis Y La Controversia De Su Usounclassified

El Cannabis como tratamiento alternativo en pacientes con Fibromialgia

Aguinsaca¹,

Molina²,

Hernández³

et al. 2023

Braz. J. Hea. Rev.

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La Fibromialgia (FM), es un trastorno reumático no articular crónico, causado por la alteración del sistema Nocioceptivo y la activación del sistema de alerta, lo cual genera dolor musculoesquueletico continuo y extenso, la presencia de puntos anatómicos sensibles a presión, y alteraciones neuroendocrinas. Es de difícil diagnóstico y su tratamiento se basa en terapias multidiciplinarias enfocadas a mantener el ritmo de vida del paciente. Sin embargo, el dolor crónico sigue siendo uno de los mayores desafíos, por lo que actualmente se ha propuesto el uso del Cannabis como medicina alternativa en pacientes con Fibromialgia, ya que los ensayos clínicos, han evidenciado efectos analgésicos, antiinflamatorios e inmunomoduladores de dos principios activos del Cannabis, el CBD y el THC. No obstante, las regulaciones estatales y la desinformación son brechas difíciles de tratar para avanzar hacia el uso clinico y seguro de este este narcótico que posee grandes oportunidades de desarrollo.

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“…Cisplatin or carboplatin-based combination therapies are standard treatments of metastatic lung cancer. 19 Alternative treatments in complement with traditional methods have been shown to be helpful in the treatment of various types of cancer, and more recently, medicinal plants [20][21][22] are reported as effective alternative treatments of lung cancer. Their anti-cancer properties include cytotoxicity (being toxic to cancer cells), inducing cancer cell apoptosis, inhibiting tumour angiogenesis and inhibiting cancer cell proliferation and growth.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence

Memarzia,

Saadat,

Asgharzadeh

et al. 2023

J Cellular Molecular Medi

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The most common type of cancer in the world is lung cancer. Traditional treatments have an important role in cancer therapy. In the present review, the most recent findings on the effects of medicinal plants and their constituents or natural products (NP) in treating lung cancer are discussed. Empirical studies until the end of March 2022 were searched using the appropriate keywords through the databases PubMed, Science Direct and Scopus. The extracts and essential oils tested were all shown to effect lung cancer by several mechanisms including decreased tumour weight and volume, cell viability and modulation of cytokine. Some plant constituents increased expression of apoptotic proteins, the proportion of cells in the G2/M phase and subG0/G1 phase, and Cyt c levels. Also, natural products (NP) activate apoptotic pathways in lung cancer cell including p‐JNK, Akt/mTOR, PI3/ AKT\ and Bax, Bcl2, but suppressed AXL phosphorylation. Plant‐derived substances altered the cell morphology, reduced cell migration and metastasis, oxidative marker production, p‐eIF2α and GRP78, IgG, IgM levels and reduced leukocyte counts, LDH, GGT, 5′NT and carcinoembryonic antigen (CEA). Therefore, medicinal plant extracts and their constituents could have promising therapeutic value for lung cancer, especially if used in combination with ordinary anti‐cancer drugs.

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Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice

Cited by 80 publications

References 31 publications

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

Exploration of In Vivo and In Vitro Biological Effects of Sonneratia caseolaris (L.) Fruits Supported by Molecular Docking and ADMET Study

El Cannabis como tratamiento alternativo en pacientes con Fibromialgia

Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence

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