Due to the rapid acceleration and evolution of the wireless communication and their equipment, integrating more services in the personal devices, Personal Digital Assistance (PDA) devices has to work in multiband frequencies. In this paper, a quad-band, dual-layer Microstrip Antenna was proposed. The proposed antenna is suggested to be used in a mobile phone handset that covers four frequency bands which include GSM 900 (889-960), GSM 1800 DCS 1800 (1710-1885)W-CDMA (Wideband Code Division Multiple Access); IMT 2000 (International Mobile Telecommunication)1885-2200, Bluetooth and Wi-Fi/WLAN (IEEE 802.11 b/g/n) ISM 2450 (Industrial, Scientific and Medical) (2400-2500). The antenna is fixed on a printed circuit board together with a standard mobile battery and LCD. All other components were packed in a mobile phone handset plastic cover. An extensive analysis of the return loss, radiation pattern, and gain of the designed antenna with and without cover were presented. Packing effects on the antenna parameters were studied, the proposed antenna shows return loss (RL) of -16 dB at 0.92 GHz; -20 dB RL at 1.735 GHz; -37 dB RL at 2.1 GHz; and -16 dB RL at 2.42 GHz which are encouraging results. Designing and simulation of the proposed antenna were based on CST software package.