Broadband terahertz recognizing conformational characteristics of a significant neurotransmitter γ-aminobutyric acid

Abstract

γ-Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the central nervous system, its conformational behavior is critical for selective biological functions and the process of signal transmission.

Vibrational spectroscopy and phonon‐related properties of monoclinic GABA, a non‐proteinogenic inhibitory neurotransmitter amino acid

“…Our Raman data also agrees well with the THz-TDS data of Cheng et al [18] for low wavenumbers smaller than 600 cm À1 , as one can see from Table 2.…”

“…A comparison between our measurements and normal mode assignments with previous experimental works using vibrational spectroscopy can be performed from Tables 1 and 2. For Table 1 we consider the recent works of Du et al [17] (2018, Raman spectrum-YDU) and Da Silva et al [16] (2017, Raman spectrum-SIL), whereas in Table 2 we compare our results with the low wavenumber measurements of Cheng et al [18] (2019) using broadband THz time-domain spectroscopy (THz-TDS). It must be noted that many maxima we measured are absent in both YDU and SIL studies.…”

“…They have obtained GABA lattice modes in the 200-650 cm À1 range with peaks at 203, 403, and 576 cm À1 (no mode assignment was performed), which are in agreement with those measured previously by Da Silva et al [16] at 203, 401, and 576 cm À1 (one can mention, however, that Da Silva et al [16] have found Raman peaks at 42, 61, 78, 108, and 117 cm À1 outside the range investigated by Du et al [17] ). Finally, Chen et al [18] applied a broadband THz time-domain spectroscopy from 0.5 to 18 THz to characterize a unique THz vibrational fingerprint of GABA.…”

Diagnosis of Glioma Molecular Markers by Terahertz Technologies

“…Its content is essentially lower in tumors of glial derivation than in normal white matter [160]. Cheng et al [161] tested the broadband THz absorption spectrum of GABA from 0.5 to 18 THz. As Figure 11 shows, GABA has a series of absorption peaks at 1.…”

“…Its content is essentially lower in tumors of glial derivation than in normal white matter [160]. Cheng et al [161] tested the broadband THz absorption spectrum of GABA from 0.5 to 18 THz. As Figure 11 shows, GABA has a series of absorption peaks at 1.13, 1.52, 2.03, 2.58, 3.48, 4.34, and 8.26 THz, and five strong and sharp absorption peaks at 5.53, 7.80, 9.63, 12.0, and 16.7 THz, respectively.…”