2024
DOI: 10.1021/acs.bioconjchem.4c00072
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Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene–Tetrazine Click Chemistry

Shelby A. Auger,
Sneha Venkatachalapathy,
Kiall Francis G. Suazo
et al.

Abstract: Bioorthogonal chemistry has gained widespread use in the study of many biological systems of interest, including protein prenylation. Prenylation is a post-translational modification, in which one or two 15-or 20-carbon isoprenoid chains are transferred onto cysteine residues near the C-terminus of a target protein. The three main enzymes�protein farnesyltransferase (FTase), geranylgeranyl transferase I (GGTase I), and geranylgeranyl transferase II (GGTase II)�that catalyze this process have been shown to tole… Show more

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