Propolis, a natural resinous substance collected by honeybees from plant and tree buds, has been recognized for its diverse biological activities and therapeutic potential. In this research, we delve into the potential of propolis collected from the Gharb region of Morocco during the summer and autumn seasons. This study aimed to highlight its nutritional profile and phytochemical compounds, shedding light on its potential as an antioxidant and a valuable product. Through detailed chemical analysis, we discern significant variations in the composition of two types of propolis coded propolis1 and propolis2, particularly evident in the elevated ash (15.23% vs. 13.83%) and lipid (23.9% vs. 15.67%) content. While protein contents (0.66% vs. 1.29%) and crude fiber (1.7% vs. 1.6%) were relatively lower. While, the phytochemical screening revealed the presence of triterpenes, steroids, flavonoids, and tannins, displaying their potential efficacy against diverse diseases. The methanolic extracts exhibited substantial total phenolic content, measuring 2130.07 mg GAE/g DP for Propolis1 and 2124.7 mg GAE/g DP for Propolis2, highlighting robust antioxidant potential. Eventually, propolis exhibited wide-ranging bioactive compounds, reflecting a potent antioxidant effect and positioning it as a miraculous product. These findings emphasize the significance of propolis as a natural resource with diverse health-promoting properties, contributing to potential applications in the cosmetic and dietary fields.