Bromelain improves decrease in defecation in postoperative rats: Modulation of colonic gene expression of inducible nitric oxide synthase

Wen, Suping; Huang, Tom; Li, George Q.; Yamahara, Johji; Roufogalis, Basil D.; Li, Yuhao

doi:10.1016/j.lfs.2005.06.007

Cited by 26 publications

(24 citation statements)

References 32 publications

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“…These enzymes are a mixture of proteinases derived from pineapple stem, which is sold as a nutritional supplement to "promote digestive health" and as an anti-inflammatory medication in some developed countries (Hale et al, 2005a and2005b;Wen et al, 2006). Bromelain is clinically used from the pineapple extract and the natural product.…”

Section: Introduction Bromelain From Pineapple Steammentioning

confidence: 99%

The effect of pH on bromelain partition from Ananas comosus by PEG4000/phosphate ATPS

Ferreira

Santana

Tambourgi

2011

Braz. arch. biol. technol.

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Section: Introduction Bromelain From Pineapple Steammentioning

confidence: 99%

The effect of pH on bromelain partition from Ananas comosus by PEG4000/phosphate ATPS

Ferreira

Santana

Tambourgi

2011

Braz. arch. biol. technol.

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“…All doses tested produced signifi cant inhibition after 7 h. It is known that indomethacin inhibits prostaglandins production (by inhibition of COX-1), while bromelain, in other experimental models, has been shown to reduce the production of NO (Wen et al, 2006) and prostaglandins (Bhui et al, 2011), as well as neutrophil migration (Fitzhugh et al, 2008). These results allow us to conclude that PPE Pm acts preferentially on the second rather than the fi rst phase of carrageenaninduced edema, which could be explained by a better bioavailability and/or increased specifi city against the release/action of mediators involved in the second phase (neutrophils, prostaglandins, and NO), whose production usually peaks between 3 and 6 h after injection of carrageenan (Salvemini et al, 1996).…”

Section: Resultsmentioning

confidence: 87%

Evaluation of Anti-Inflammatory Activity of Pseudananas macrodontes (Morr.) Harms (Bromeliaceae) Fruit Extract in Rats

Errasti

Caffini

Pelzer

et al. 2013

Zeitschrift Für Naturforschung C

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Several species of the family Bromeliaceae are characterized by the production of proteases in unusual amounts, especially in fruits. Bromelain, an extract rich in cysteine endopeptidases obtained from Ananas comosus L., and a few other proteases have been used as anti-infl ammatory agents for some years, but bromelain is still mainly being used as alternative and/or complementary therapy to the treatment with glucocorticoids, nonsteroidal antirheumatics, and immunomodulators. In this study, the anti-infl ammatory action of a partially purifi ed extract from Pseudananas macrodontes (Morr.) Harms fruits (PPE Pm ) is presented, whose main components are cysteine endopeptidases. The effect of PPE Pm was assessed in carrageenan-induced and serotonin-induced rat paw edema, as well as in the cotton pellet granuloma model. Doses with equal proteolytic activity of PPE Pm and bromelain produced signifi cantly similar anti-infl ammatory responses in the acute infl ammatory models assayed, supporting the hypothesis that proteolytic activity could be responsible for the anti-infl ammatory action. On the contrary, comparable anti-infl ammatory effects of PPE Pm and bromelain in the chronic infl ammatory assay required a much lower proteolytic activity content of PPE Pm , which could be due to a differential affi nity for the protein target involved in this process.

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“…In OA the apoptosis of chondrocyte cells involves the activity of nitric oxide (NO), inducible nitric oxide synthase (iNOS), COX-2, and prostaglandin E2 (PGE2) (Blanco, 1999;Goldring, 2000;Sandell and Aigner, 2001;Nesic et al, 2006). From our preliminary studies, we suspect that because bromelain exerts an inhibitory effect on NO, iNOS, COX-2 and PGE2 (Oh-ishi et al, 1979;Wen et al, 2006;Kalra et al, 2008), bromelain significantly decreases the rate of apoptosis and increases chondrocyte proliferation. Following from these results it will be interesting to elucidate the different actions of bromelain treatment on further cellular targets.…”

Section: Discussionmentioning

confidence: 99%

Effects of bromelain on cellular characteristics and expression of selected genes in canine in vitro chondrocyte culture

Siengdee¹,

Nganvongpanit²,

Pothacharoen³

et al. 2010

Vet. Med. - Czech

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ABSTRACT:The purpose of this study was to determine the effect of bromelain treatment on canine articular chondrocytes in vitro. This research evaluated cell viability, levels of apoptotis and mitotis, proteoglycan concentrations and the expression of certain genes. Chondrocytes were exposed to 50 μg/ml bromelain for 4, 16 and 32 h. The rate of apoptotis in the treatment groups was significantly lower than in the control groups that were incubated with media only (P < 0.05); and the mitotic rate in treatment groups was significantly higher than in the control groups (P < 0.05), at all durations of exposure. The effect of bromelain on gene expression was measured by the real-time PCR technique. It was found that bromelain significantly decreased (P < 0.05) TIMP-1 and MMP-3 expression. These experimental bromelain treatments have shown positive results, and have increased the basic knowledge in regard to the healing and modulation of osteoarthritis, prior to the general use of bromelain in clinical practice.

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Bromelain improves decrease in defecation in postoperative rats: Modulation of colonic gene expression of inducible nitric oxide synthase

Cited by 26 publications

References 32 publications

The effect of pH on bromelain partition from Ananas comosus by PEG4000/phosphate ATPS

The effect of pH on bromelain partition from Ananas comosus by PEG4000/phosphate ATPS

Evaluation of Anti-Inflammatory Activity of Pseudananas macrodontes (Morr.) Harms (Bromeliaceae) Fruit Extract in Rats

Effects of bromelain on cellular characteristics and expression of selected genes in canine in vitro chondrocyte culture

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