Bromhexine Hydrochloride Eliminates Protein Plugs and Relieves Attacks of Pancreatitis

Noda, Aiji; Ibuki, Eri; Murayama, H.; Hase, Satoshi

doi:10.1097/00006676-199708000-00014

Cited by 9 publications

(6 citation statements)

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“…The major component of the plugs in chronic pancreatitis is also lithostathine [14]. From the present results, the effect of bromhexine in chronic pancreatitis patients may rely not on the dissolution of the plugs, but on the lowering of the viscosity of pancreatic juice, as Noda et al speculated [11]. We also tested a semisynthetic bile acid, expecting its surfactant effect, but it was ineffective.…”

Section: Discussionmentioning

confidence: 58%

“…Plugs required a longer time to dissolve than in citric acid solution, leaving transparent residues in both Case 1 (upper right) and Case 2 (lower right), which did not dissolve any further. The reason why the residues were different from other solutions is unknown ducts, as well as alleviated symptoms in patients with chronic pancreatitis [11,12]. The major component of the plugs in chronic pancreatitis is also lithostathine [14].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, agents that dissolve protein plugs can be applied for the relief or prevention of symptoms. To identify such agents, we tested drugs reportedly effective for the dissolution of pancreatic stones and a semisynthetic bile acid with a surfactant effect, and assessed whether they could dissolve protein plugs obtained from choledochal cyst patients [8][9][10][11][12]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acidic and Basic Solutions Dissolve Protein Plugs Made of Lithostathine Complicating Choledochal Cyst/Pancreaticobiliary Maljunction

et al. 2008

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acidic and Basic Solutions Dissolve Protein Plugs Made of Lithostathine Complicating Choledochal Cyst/Pancreaticobiliary Maljunction

et al. 2008

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“…(21). In another patient with non-alcoholic chronic pancreatitis, a protein plug disappeared after bromhexine hydrochloride was administered for four and a half months (22).…”

Section: Discussionmentioning

confidence: 99%

Mediastinal Pancreatic Pseudocyst Caused by Obstruction of the Pancreatic Duct Was Eliminated by Bromhexine Hydrochloride

et al. 2004

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A 49-year-old man, who had a 30-year history of drinking the equivalent of 80 g of ethanol per day, underwent a detailed medical examination for cough and dyspnea. Chest-abdominal computed tomography and endoscopic retrograde pancreatography led to the diagnosis of a mediastinal pancreatic pseudocyst resulting from obstruction of the pancreatic duct by a protein plug. The pseudocyst rapidly improved with conservative treatment with camostat mesilate, H2-receptor antagonist and digestive enzymes. Although the patient abstained from alcohol for approximately 6 months, he resumed drinking, leading to recurrent attacks of pancreatitis. Bromhexine hydrochloride was then administered for 6 months, with the expectation that it would have a mucolytic effect on the pancreatic juice, resulting in improvement in the clinical symptoms, pancreatic enzymes and pancreatic exocrine function, as well as elimination of the protein plug. Bromhexine hydrochloride may be a new therapy for pathological states, such as alcoholic chronic pancreatitis, in which there is increased viscosity of the pancreatic juice because of elevated protein concentration, leading to protein plug formation and temporary blockage of the pancreatic duct.

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“…The collected materials were white and fragile, and they were found to be more than 90% protein. Since the procedure, the patient has been well without symptoms with bromhexine hydrochloride treatment [1]. Protein plugs sometimes cause symptoms in children with choledochal cyst [2].…”

Section: A Ercp Showed Several Small Filling Defects In the Remnant Cmentioning

confidence: 99%

Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst

Chiba

Kamisawa

Egawa

2010

J Hepato Biliary Pancreat

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A 49-year-old female was admitted to our hospital because of abdominal and back pains. She had undergone cystojejunostomy for a congenital choledochal cyst with pancreaticobiliary maljunction at the age of 11 years, and then underwent resection of the choledochal cyst, hepaticojejunostomy, and transduodenal sphincteroplasty at the age of 26 years. However, from 40 years of age, she had suffered from mild acute relapsing pancreatitis once every 1-2 years.On admission, the serum amylase level was elevated to 1001 IU/l. Endoscopically, white plugs were seen to be floating beyond the post-plasty papilla. ERCP showed Fig. 1 a ERCP showed several small filling defects in the remnant cyst and slightly dilated main pancreatic duct near the papilla. b Schematic illustration

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Bromhexine Hydrochloride Eliminates Protein Plugs and Relieves Attacks of Pancreatitis

Cited by 9 publications

References 0 publications

Acidic and Basic Solutions Dissolve Protein Plugs Made of Lithostathine Complicating Choledochal Cyst/Pancreaticobiliary Maljunction

Acidic and Basic Solutions Dissolve Protein Plugs Made of Lithostathine Complicating Choledochal Cyst/Pancreaticobiliary Maljunction

Mediastinal Pancreatic Pseudocyst Caused by Obstruction of the Pancreatic Duct Was Eliminated by Bromhexine Hydrochloride

Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst

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