Bromide Kinetics and Distribution in the Rat. I. : Biokinetics of ⁸²Br-Bromide

Abstract

Biological half-lives of bromine in 15 different organs and tissues of the rat, in addition to the whole-body half-life, were determined by measuring the radioactive concentration of 82Br-bromide in samples of tissues collected at the time intervals of 12-396 h from animals that continuously (up to 17 d) received 82Br-labeled bromide in their drinking water. The half-life values, calculated from the experimental data by the method of gradual estimates of the parameters in question with the SPSS statistical program, ranged from 94.3+/-14.6 h in the thyroid gland to 235.0+/-88.9 h in liver. In most of the studied tissues, the biological half-lives of bromine were shorter than in the whole body, in which it equaled 197.8+/-22.2 h. Significant correlation between the values of the steady-state concentration of bromide and of the biological half-life was found for most tissues (except for liver). The steady-state concentrations of 82Br in tissues are probably proportional to the magnitude of bromide space, and, consequently, of chloride space.

Pharmacokinetics and Clinical Utility of Sodium Bromide (NaBr) as an Estimator of Extracellular Fluid Volume in Horses

“…Both of these uses require knowledge of bromide pharmacokinetic properties. The disposition kinetics have been described in humans, 9 dogs, 10 rats, 11 and ruminants. 12 The elimination half-life of bromide varies markedly between species, ranging from 9.4 days in humans 9 to 14 days in cows 12 and 37 days in dogs.…”

Bromine

“…After oral ingestion, bromide is rapidly and completely absorbed in the gastrointestinal tract and, analogously to chloride, distributed almost exclusively in the extracellular fluid (with the exception of erythrocytes). In addition to the whole-body half-life, Pavelka et al (2000a) determined biological half-lives of bromine in 15 different organs and tissues of the rat. The similarity of bromide to chloride entails an important pharmacokinetic interaction; both ions compete for tubular reabsorption (Rauws 1983).…”

Halothane Exposure and Serum Bromide Measurements for Healthcare Professionals Working in Surgical Theatres in Jordanian Hospitals = قياس مستويات البروميد في مص الدم للكادر الطبي و التمريضي العامل في غرف العمليات في المستشفيات الأردنية التي تستخدم مادة الهالوثين

“…(11) It has been reported in literature that the half life (t 1/2 ) in human is about 12 days that might be increased by salt-deficient diet and the main route of excretion is by renal in a rate of 5% the administered dose per hour. (12) It has been reported in literature that the maximum allowed serum bromide level is 3.2-4.8 mg/l and as this level increased, bromide toxicity increased. (13) Researchers assume that healthcare workers in operation rooms (Ors), because of their long exposure to anesthesia, are the most susceptible to Halothane toxicity and high levels of bromide and Triflouroacetate are expected in their blood and strongly support the use of proper scavenging system in the anesthetic circuit to control the level of gases in Ors.…”