Brominated Metabolites from the Marine Red Alga Laurencia similis

Li, Chun‐Shun; Li, Xiaoming; Cui, Chuan‐Ming; Wang, Bin‐Gui

doi:10.1515/znb-2010-0115

Cited by 15 publications

(9 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…448 A brominated aristolane-type sesquiterpene 355 was obtained from L. similis (Hainan Is., China). 449 The cuparenederived sesquiterpene 8,10-dibromo-3,7-epoxy-laur-13-ol 356 was isolated from Laurencia sp. (South China Sea).…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2012

View full text Add to dashboard Cite

Covering: 2010. Previous review: Nat. Prod. Rep., 2011, 28, 196. This review covers the literature published in 2010 for marine natural products, with 895 citations (590 for the period January to December 2010) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1003 for 2010), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

show abstract

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Nonetheless, up to now 14 aristolanes (450-463) have been reported from such sources. Aristolan-1α-bromo-9β,10β-epoxide (463), isolated from Laurencia similis collected in Hainan Island, People's Republic of China, is the only halogenated derivative characterized so far [431]. …”

Section: Aristolanesmentioning

confidence: 99%

The Laurencia Paradox: An Endless Source of Chemodiversity

Harizani

Iοannou

Roussis

2016

Progress in the Chemistry of Organic Natural Products

View full text Add to dashboard Cite

Nature, the most prolific source of biological and chemical diversity, has provided mankind with treatments for health problems since ancient times and continues to be the most promising reservoir of bioactive chemicals for the development of modern drugs. In addition to the terrestrial organisms that still remain a promising source of new bioactive metabolites, the marine environment, covering approximately 70% of the Earth's surface and containing a largely unexplored biodiversity, offers an enormous resource for the discovery of novel compounds. According to the MarinLit database, more than 27,000 metabolites from marine macro- and microorganisms have been isolated to date providing material and key structures for the development of new products in the pharmaceutical, food, cosmeceutical, chemical, and agrochemical sectors. Algae, which thrive in the euphotic zone, were among the first marine organisms that were investigated as sources of food, nutritional supplements, soil fertilizers, and bioactive metabolites.Red algae of the genus Laurencia are accepted unanimously as one of the richest sources of new secondary metabolites. Their cosmopolitan distribution, along with the chemical variation influenced to a significant degree by environmental and genetic factors, have resulted in an endless parade of metabolites, often featuring multiple halogenation sites.The present contribution, covering the literature until August 2015, offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. Since mollusks feeding on Laurencia are, in many cases, bioaccumulating, and utilize algal metabolites as chemical weaponry against natural enemies, metabolites of postulated dietary origin of sea hares that feed on Laurencia species are also included in the present review. Altogether, 1047 secondary metabolites, often featuring new carbocyclic skeletons, have been included.The chapter addresses: (1) the "Laurencia complex", the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; (2) the secondary metabolites, which are organized according to their chemical structures and are classified into sesquiterpenes, diterpenes, triterpenes, acetogenins, indoles, aromatic compounds, steroids, and miscellaneous compounds, as well as their sources of isolation which are depicted in tabulated form, and (3) the biological activity organized according to the biological target and the ecological functions of Laurencia metabolites.

show abstract

“…2,3,4,6-Tetrabromo-1-methyl-1 H -indole ( 29 ) was isolated from the marine red alga Laurencia decumbens [ 41 ]. 3,5,6-Tribromo-1 H -indole ( 30 ), 3,5,6-tribromo-1-methyl-1 H -indole ( 31 ), 2,3,6-tribromo-1 H -indole ( 32 ), 3,5-dibromo-1-methyl-1 H -indole ( 33 ) and 2,5-dibromo-1-methyl-1 H -indole ( 34 ) have been isolated from the marine red alga Laurencia similis [ 42 , 43 , 44 ]. 6-Bromo-1 H -indole-3-carboxamide ( 35 ) was obtained from the marine sponge Mycale fibrexilis [ 45 ].…”

Section: Marine Indole Alkaloidsmentioning

confidence: 99%

Marine Indole Alkaloids

2015

View full text Add to dashboard Cite

Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed.

show abstract

Brominated Metabolites from the Marine Red Alga Laurencia similis

Cited by 15 publications

References 6 publications

Marine natural products

Marine natural products

The Laurencia Paradox: An Endless Source of Chemodiversity

Marine Indole Alkaloids

Contact Info

Product

Resources

About