Bromination products of furfural

Synthesis of Some Diazine and Triaazole Derivatives From Furfural

“…The above compounds were prepared from the treatment of compound (8) with Dimethyl cyclohexene, acetylene dicarboxylate (DMAD) and dichloro ethylene as it was stated in the experimental part the reaction involve 1,3-diplor addition between (DMAD) and the azido group resulted into the formation of the corresponding triazoles. compound (9) as shown in scheme (1) Compound (9) was afforded by treatment of cap ( 8) with DMAD while compounds 10 and 11 were obtained by treatment of compound ( 8) with cyclohexene and dichloro ethylene respectively. All compounds were characterized by the following IR main absorption bands : cm -1 : 1640-1661 for C=N and C=O of amide group while the aromatic C=C absorbed within the same of C=N region the ester stretching bands appeared at 1739 and finally the C-Cl stretching band absorbed at 721 Cm -1 .…”

“…Accordingly, heterocyclic compounds were found to be used for many biological, clinical and pharmaceutical applications [5][6][7]. Furfural for example 2-(2-furyl) [1,3] dioxane,5-nito(1,3-imidazolyl-2,5-dion)-3-yl furfurlidine was found to be used for treatment of urinary tract [8][9][10] also furfural derivatives were used for different biological applications [11,12] It was also known that many triazoles and diazines compounds were synthesized from different routes [13][14][15][16] . Some heterocyclic compound derived from furfural were prepared previously [17] and here we are going to complete this work by using furfural as precursor for other new heterocyclic compounds which might find an applications as drugs ,since Triazoles such as fluconazole, Isavuconazole, Hexaconazole, epoxiconazole, difenoconazole, tebuconazole etc.,) were commercially used as a fungicidal drugs [18].…”

Synthesis of Some Heterocyclic Compounds Derived from Furfural Using Ultrasonic Waves

“…Furfural itself and its derivatives MCA, MBA for example 4,5-Dibromofurfuraldehydle, 2-(2-furyl) [1,3] dioxane,5nito(1,3-imidazolyl-2,5-dion)-3-yl furfuraldine was used as drag in treatment of urinary tract [7,8]. Among the reactions of furfural are the synthesis of tetrazine derivatives [9], furyl methylene diacetate [10] and 4-methyl furfural [11]. Among the known reactions of furfural which leads to the formation of heterocyclic compounds are the synthesis of 1,3-imidizolyl-2,5-furfuryl amine-2,s5-dione which is used for treatment of urinary tract infections [12].…”