Bromophenacyl bromide, a phospholipase A₂inhibitor attenuates chemically induced gastroduodenal ulcers in rats

Abstract

BPB possesses significant antiulcer and cytoprotective activity against experimentally induced gastroduodenal lesions.

2,3‐Dimercaptopropanol, a thiol chelator, alleviates gastroduodenal ulcers in rats

“…Sulfhydryl compounds play an important role in the formation of gastrointestinal mucus, which protects underlying gastric mucosa against necrotizing agents [55,56]. There was a significant depletion of NP-SH content in the gastric mucosa of rats treated with ethanol alone (Table II), which is in agreement with earlier reports [14,30,57]. The treatment of animals with DMP significantly and dose dependently reversed ethanol-induced depletion of NP-SH (Table II).…”

Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage byGymnema sylvestrein male Wistar albino rats

“…However, gastric wall mucus plays a more important role in the defense of the gastric mucosa against chemical aggression than the soluble mucus in the lumen of the stomach (Allen et al, 1986). This gastric mucus coat may facilitate the repair of the damaged gastric epithelium (Tariq et al, 2006). In the present study, G. sylvestre was found to inhibit the depletion of stomach-wall mucus caused by ethanol treatment.…”

Effects of increase in fish oil intake on intestinal eicosanoids and inflammation in a mouse model of colitis

“…In that respect, new tricks that could be translated to human clinics, to improve n3-derived lipid metabolites generation or n3:n6 ratio in vivo deserve further investigations. This could be achieved by the concomitant use of dietary FO with phospholipase A2 inhibitors (to reduce AA release and generation of proinflammatory eicosanoids [46]) and or COX-2 inhibitors (to promote resolvins generation [47]).…”