Bronchial and cutaneous responses in atopic dermatitis patients after allergen inhalation challenge

Abstract

We conclude that allergen inhalation challenge causes a flare up of the skin lesions in atopic dermatitis patients. This was more prominent in atopic dermatitis patients who already suffered from an IgE-mediated allergic inflammation in the lung.

Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber

“…Bronchial hyperresponsiveness to methacholine in patients with AD revealed a more prominent flare-up of skin symptoms in those patients with AD who already had IgE-mediated inflammation of the lung. 26 Tupker et al 24 also observed that all patients with AD with a skin reaction on bronchial exposure to house dust mite had a history of asthma.…”

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation

“…Among patients being treated for eczema, allergen inhalation challenge caused a flare-up of skin lesions in patients, which was worse in those with allergic asthma. 16 The same authors examined early and late asthmatic responses after allergen inhalation challenge in groups of patients with varying degrees of atopic dermatitis and asthma. 17 After bronchial challenge, patients with atopic dermatitis and without asthma demonstrated increased bronchial responsiveness and early asthmatic responses, suggesting a latent predisposition to bronchial asthma.…”

Systemic effects of local allergic disease

“…In 1997, Brinkman et al showed that dustmite allergen inhalation challenge can cause a flare up of skin lesions in patients with pre-existing atopic dermatitis and dust-mite sensitization. 25 The worsening in the clinical score for dermatitis occurred around 24 hours after the inhalation challenge and no acute cutaneous symptoms were noted. Interestingly, the effect of the inhalation challenge on the skin was more pronounced in the subjects who also had asthma, as opposed to those who only had allergic rhinitis.…”