Bronchial carcinoma and hyperkeratosis palmaris et plantaris

Powell, Frank C.; Mackey, J. P.

doi:10.1136/pgmj.57.663.57

Cited by 17 publications

(4 citation statements)

References 7 publications

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“…Nonfamilial or acquired forms of PPK may also be associated with malignancy, such as cancer of the esophagus, lung, breast, urinary tract, and stomach. [6][7][8][9] The feet are often more severely involved than the hands, possibly due to mechanical pressure. In addition, the dorsum of the acral areas and the nails are generally not involved.…”

Section: Discussionmentioning

confidence: 99%

“…Its association with esophageal strictures, 2 squamous cell carcinoma of the skin, 3 carcinoma of the stomach and the larynx, 4 and oral leukoplakia 5 was described later by others. Nonfamilial or acquired forms of PPK may also be associated with malignancy, such as cancer of the esophagus, lung, breast, urinary tract, and stomach 6–9 . The feet are often more severely involved than the hands, possibly due to mechanical pressure.…”

Section: Discussionmentioning

confidence: 99%

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Lung carcinoma with congenital plantar keratoderma as a variant of Clarke‐Howel‐Evans syndrome

et al. 2003

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A 32‐year‐old man was admitted to the Magdeburg University Hospital with icterus and for further diagnosis of suspected hepatitis. He also complained of generalized pruritus, abdominal pain, nausea, and diarrhea. The patient's history revealed the excision of a lymph node metastasis of the left groin showing pleomorphic macrocellular infiltrates, 2 months previously. The patient presented to our department with prominent hyperkeratosis of both feet, which had been present since early youth. The family history was negative. Both soles showed very thick, white and blackish hyperkeratosis with predominance of the heels and the forefeet (Fig. 1). The naturally occurring wrinkles of the skin of the toes were flattened. The palms were not affected, and neither was the oral mucosa. Further investigations revealed icterus of the sclera and multiple, firm tumors, which were located in the deep subcutaneous tissue, on the left hip, thigh, and buttock. From thorough clinical, laboratory and staging investigations, a non‐small‐cell bronchogenic carcinoma, with metastases of the liver, kidneys, adrenal glands, and several skin sites, was diagnosed. 1 Plantar surface of the feet showing very thick, white and blackish hyperkeratosis with predominance of the heels and the forefeet A skin biopsy specimen of the foot showed substantial acanthosis of the epidermis with hypergranulosis and excessive orthohyperkeratosis. The corneocytes were enlarged and arranged in a tile‐like pattern (Fig. 2). The dermis was free of inflammatory infiltrates and human papillomavirus infection was ruled out by immunohistochemistry. 2 Dermatohistopathology revealing massive acanthosis of the epidermis with hypergranulosis, substantial orthohyperkeratosis, and a tile‐like pattern of the stratum corneum (hematoxylin and eosin, × 200) Polychemotherapy was immediately started with 5‐fluorouracil, mitomycin, and cisplatin, which was well tolerated. When the patient was admitted for the second cycle, however, his general health had worsened markedly. He complained of abdominal pain, severe weight loss, and nausea. Generalized metastases showed substantial progression. Chemotherapy could not be continued because of a Karnowsky index below 20%. The patient died 2 weeks later.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lung carcinoma with congenital plantar keratoderma as a variant of Clarke‐Howel‐Evans syndrome

et al. 2003

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“…Acta Dermatovener (Stockholm/ 62 tion � ith occult bronchogenic carcinoma and perhaps other malignancies seems undeniable: im provement in the keratoderma following treatment of the lung lesion has bcen reported (10). The dc velopmcnt of acquired keratoderma should con sequently prompt thorough investigation for the pos�ible presence of occult neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Palmo-plantar keratoderma associated with carcinoma of the bronchus

Kerdel,

MacDonald

1982

Acta Derm Venereol

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“…Davon abgrenzen muß man solche Fallbeschreibungen, bei denen sich tylotische Hautveränderungen erstmals im Zusammenhang mit einem Malignom oder einer Ösophagusstriktur manifestieren [12,18,24,25,29,30,32,33] und die eher den Charakter eines paraneoplastischen Phänomens haben.…”

Section: Stammbaum Der Familie Und Ergebnisse Der Klinischen Nachunteunclassified

Das Clarke-Howel-Evans-McConnell-Syndrom

Simón

Hagedorn

1997

Der Hautarzt

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The Clarke-Howel-Evans-McConnell syndrome is a rare hereditary disease characterized by palmoplantar keratoses, squamous cell carcinoma of the esophagus and oral leukoplakia. According to a new classification recently proposed by Stevens and colleagues, the syndrome can also be classified as palmoplantar ectodermal dysplasia type III. We report a family from the Black Forest region of Germany afflicted with the syndrome. The family was traced through five generation. 27 of 46 family members showed tylotic skin changes. In addition, 8 patients showed oral leukoplakia and 5 died from squamous cell carcinoma of the esophagus. Using screening examinations, early changes of the esophageal mucosa could be detected. The responsible gene has been mapped in the family. It is located at 17q23-qter, telomeric to the keratin II gene cluster. Therefore a defect in one of the well known keratin genes can be excluded as a cause of the syndrome.

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Bronchial carcinoma and hyperkeratosis palmaris et plantaris

Cited by 17 publications

References 7 publications

Lung carcinoma with congenital plantar keratoderma as a variant of Clarke‐Howel‐Evans syndrome

Lung carcinoma with congenital plantar keratoderma as a variant of Clarke‐Howel‐Evans syndrome

Palmo-plantar keratoderma associated with carcinoma of the bronchus

Das Clarke-Howel-Evans-McConnell-Syndrom

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