Bronchiectasis: epidemiology and causes

Bilton, D.; Jones, A. L.

doi:10.1183/1025448x.10003110

Cited by 22 publications

(16 citation statements)

References 41 publications

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“…Although there is no validated score for daily clinical practice, the Bhalla score includes several elements that measure the extent and severity of bronchiectasis and other radiologic features associated with them [10].While other scales scarcely used in literature have some advantages in accuracy or good inter-observer variability, Bhalla score may show the severity of the disease more completely. The severity of bronchiectasis was significantly associated with age, smoking history, airflow limitation, lower FEV1, more frequent emphysema and coronary calcium, as previously seen in other studies [7,12,[28][29][30] Airflow limitation is quite common in patients with bronchiectasis [31][32][33] and was found in 55% of individuals with bronchiectasis in our cohort compared to 45% of the controls. In a study of 200 patients with bronchiectasis, airway obstruction was found in 43% and the presence and severity of airflow obstruction was proportional to the severity of bronchiectasis regardless of pack-years, sex or age [3].The finding of bronchiectasis in asymptomatic individuals, albeit mild in most instances, underlines the underdiagnosis of this condition.…”

Section: Burden Of Bronchiectasissupporting

confidence: 87%

Prevalence and burden of bronchiectasis in a lung cancer screening program

et al. 2020

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Introduction The prevalence of bronchiectasis in the general population and in individuals undergoing lung cancer screening with low dose computed tomography (LDCT) is unknown. The aim of this study is to estimate the prevalence and impact of bronchiectasis in a screening lung cancer program. Methods 3028 individuals participating in an international multicenter lung cancer screening consortium (I-ELCAP) were selected from 2000 to 2012. Patients with bronchiectasis on baseline CT were identified and compared to selected controls. Detection of nodules, need for additional studies and incidence of cancer were analyzed over the follow-up period. Results The prevalence of bronchiectasis was 11.6%(354/3028). On the baseline LDCT, the number of subjects with nodules identified was 189(53.4%) in patients with bronchiectasis compared to 63(17.8%) in controls (p<0.001). The occurrence of false positives was higher in subjects with bronchiectasis (26%vs17%;p = 0.003). During follow-up, new nodules were more common among subjects with bronchiectasis (17%vs.12%; p = 0.008). The total number of false positives during follow-up was 29(17.06%) for patients with bronchiectasis vs. 88(12.17%) for controls (p = 0.008).The incidence rate of lung cancer during follow-up was 6.8/1000 and 5.1/1000 person-years for each group respectively (p = 0.62) Conclusions Bronchiectasis are common among current and former smokers undergoing lung cancer screening with LDCT. The presence of bronchiectasis is associated with greater incidence

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Section: Burden Of Bronchiectasissupporting

confidence: 87%

Prevalence and burden of bronchiectasis in a lung cancer screening program

et al. 2020

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“…The estimated prevalence of BE in the United States ranges from 4 per 100,000 young adults to almost 300 per 100,000 in those more than 75 years old (2)(3)(4)(5). British Thoracic Society guidelines indicate that management should be focused on improving or maintaining lung function, reducing exacerbations, and improving HRQoL (1,6).…”

mentioning

confidence: 99%

Lung Clearance Index Is a Repeatable and Sensitive Indicator of Radiological Changes in Bronchiectasis

Rowan

Bradley

Bradbury

et al. 2014

Am J Respir Crit Care Med

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“…Given a common inflammatory process several pathways can lead to the development of bronchiectasis and a classification might reflect the following categories [3]: structural lung condition, toxic damage to airways, obstruction of single bronchi, obstructive airways disease, defect of mucociliary clearance, allergic bronchopulmonary aspergillosis, immunodeficiency, infections, bronchiectasis in systemic diseases, idiopathic disease.…”

mentioning

confidence: 99%