Bronchioalveolar carcinoma in an adult alpaca (Vicugna pacos)

Moser, Lara; Kegler, Kristel; Precht, Christina; Zanolari, Patrik

doi:10.1186/s12917-019-1895-8

Cited by 7 publications

(8 citation statements)

References 13 publications

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“…This is the first description of the diagnoses and treatment of a geriatric alpaca with multiple neoplasms. So far, only single case reports have documented an SCC, pulmonary adenocarcinoma or urinary polyp 2 7 11. In the present study, the finding of concurrent primary lung neoplasia, urinary proliferation and metastasising SCC is atypical, and the advanced age of the animal is likely to be an important contributing factor.…”

Section: Discussionmentioning

confidence: 42%

“…This is the first report of a metastasising SCC in an alpaca with multiple other proliferative lesions. Primary pulmonary neoplasia is also uncommon, with only one case reported in this species 7. In addition, the alpaca in this case had a focally extensive polyp in the urinary bladder, which is a very rare cause of acute urine retention 11…”

Section: Introductionmentioning

confidence: 82%

“…Despite neoplasms being relatively commonly diagnosed in South American camelids, with lymphomas, squamous cell carcinomas (SCC) and adenocarcinomas being diagnosed most often in llamas, SCC has rarely been described in alpacas 1–10. The overall prevalence of neoplasia appears to be higher in llamas than in alpacas 2 5 10.…”

Section: Introductionmentioning

confidence: 99%

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Management of a geriatric alpaca with multiple neoplasms in a zoological setting

Moittié

Dobbs²,

Waine

et al. 2020

Vet Record Case Reports

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During a routine health check, a 22-year-old female alpaca presented with an infected mass on the sternal pad. A squamous cell carcinoma was diagnosed on histopathology. Systemic antibiotics and topical treatment were initiated. Thoracic radiographs and blood analysis showed no abnormalities; therefore, surgical resection was performed, and the wound was allowed to heal by second intention with therapeutic laser therapy. The treatment plan for this animal was developed with the collaboration of the keeping team and zoo managers and considered the health status of the animal, overall prognosis and the possibility of frequent restraints with minimal stress. Six months after initial presentation, the alpaca showed dramatic weight loss and severe urine scalding with a mass identified in the urinary bladder and was euthanased on welfare grounds. Postmortem findings included squamous cell carcinoma metastases in the tributary lymph nodes and in the lung, adenocarcinoma in the lung, and a polyp in the urinary bladder.

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Section: Discussionmentioning

confidence: 42%

Section: Introductionmentioning

confidence: 82%

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Management of a geriatric alpaca with multiple neoplasms in a zoological setting

Moittié

Dobbs²,

Waine

et al. 2020

Vet Record Case Reports

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“…Primary pulmonary adenocarcinomas have previously been reported in llamas (Lama glama) with confirmed metastases to the pleura, liver and possibly the femur in one case 3 and pleura, liver, kidney and heart in another case. 4 Recently, Moser et al 5 reported a case of bronchioalveolar carcinoma in a six-year-old huacaya alpaca presenting with respiratory signs (dyspnoea and abdominal breathing) and weight loss despite having a good appetite. Multiple pulmonary nodules were detected on ultrasonographic, radiographic and CT examination and were diagnosed as bronchioalveolar carcinomas on histological examination.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary adenocarcinoma in two alpacas (Vicugna pacos)

Moore

Wessels²,

McFadzean

et al. 2020

Vet Record Case Reports

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We describe here two cases of pulmonary neoplasia in alpacas: case 1 was a 19‐year‐old female huacaya alpaca that was submitted to investigate sudden death with possible previous weight loss. Gross and histological examination revealed changes consistent with primary lepidic‐type pulmonary adenocarcinoma (previously bronchioalveolar carcinoma) with metastases to the thorax and abdomen. Case 2 was a six‐year‐old male castrated Suri alpaca with a 3‐week history of weight loss and inappetance that was euthanased following a short period of recumbency and respiratory signs. Gross and histological features in this case were consistent with a diagnosis of metastatic adenocarcinoma affecting the lungs and lymph nodes. Masses from both alpacas were further characterised using immunohistochemistry for thyroid transcription factor 1 (TTF‐1), pan cytokeratin AE1/AE3 and vimentin. We show that histological subtype and TTF‐1 and AE1/AE3 immunoreactivity can be used to differentiate primary and metastatic pulmonary adenocarcinomas in the lungs of alpacas.

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“…Final diagnosis could not be distinguished between simple tubular carcinoma or mammary ductal carcinoma due to the anaplastic nature of the neoplasm. Previously reported neoplasms in alpacas include fibroma, fibropapilloma, lymphoma, interstitial cell tumor, primitive stromal cell tumor, pancreatic adenocarcinoma, and carcinoma of bronchoalveolar, ocular and of undifferentiated origin 1,2 . Mammary carcinoma of ductal origin has previously been reported in a llama but that case was associated with significant distant metastasis 3…”

Section: Descriptionmentioning

confidence: 99%