Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria

Estenne, Marc; Maurer, J.R.; Boehler, Annette; Egan, J. J.; Frost, Adaani E.; Hertz, Marshall I.; Mallory, George B.; Snell, Gregory I; Yousem, Samuel A.

doi:10.1016/s1053-2498(02)00398-4

Cited by 1,189 publications

(1,074 citation statements)

References 105 publications

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“…For over 10 years BOS has been defined as a persistent, obstructive decline in forced expiratory volume in 1 second (FEV 1 ) in the absence of confounding factors (2). However, nowadays the term chronic lung allograft dysfunction (CLAD) seems more appropriate as it became clear that there are different phenotypes of chronic rejection.…”

Section: Survival Remains Hampered By Chronic Rejection Of Which the mentioning

confidence: 99%

Functional and computed tomographic evolution and survival of restrictive allograft syndrome after lung transplantation

Verleden

Jong

Ruttens

et al. 2014

The Journal of Heart and Lung Transplantation

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Section: Survival Remains Hampered By Chronic Rejection Of Which the mentioning

confidence: 99%

Functional and computed tomographic evolution and survival of restrictive allograft syndrome after lung transplantation

Verleden

Jong

Ruttens

et al. 2014

The Journal of Heart and Lung Transplantation

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“…28 A secondary cascade of non-specific inflammatory mediators attracts other cells, including neutrophils, and leads to migration of fibroblasts, proliferation of smooth muscle cells, and eventually collagen deposition and fibrous obliteration of the lumen. 29,30 Interestingly, studies of BOS in lung transplant recipients have suggested a central role of T-cell-mediated reactivity towards collagen. Thus, infiltrating monocytes as well as collagen type V (col(V))-specific Th17 cells are seen in the inflammatory focus.…”

Section: Pathogenesismentioning

confidence: 99%

Bronchiolitis obliterans after allo-SCT: clinical criteria and treatment options

Uhlving

Buchvald

Heilmann

et al. 2011

Bone Marrow Transplant

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Bronchiolitis obliterans (BO) following allogeneic haematopoietic SCT (HSCT) is a serious complication affecting 1.7-26% of the patients, with a reported mortality rate of 21-100%. It is considered a manifestation of chronic graftversus-host disease, but our knowledge of aetiology and pathogenesis is still limited. Diagnostic criteria are being developed, and will allow more uniform and comparable research activities between centres. At present, no randomised controlled trials have been completed that could demonstrate an effective treatment. Steroids in combination with other immunosuppressive drugs still constitute the backbone of the treatment strategy, and results from our and other centres suggest that monthly infusions of high-dose pulse i.v. methylprednisolone (HDPM) might stabilise the disease and hinder progression. This article provides an overview of the current evidence regarding treatment options for BO and presents the treatment results with HDPM in a paediatric national HSCT-cohort.

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“…18 Early predictive markers are lacking. 15 Its connection with alloimmunity is based partly on a correlation with the severity of prior acute rejection.…”

mentioning

confidence: 99%

Transcript Signatures of Lymphocytic Bronchitis in Lung Allograft Biopsy Specimens

Golden

Dolganov³

et al. 2005

The Journal of Heart and Lung Transplantation

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Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria

Cited by 1,189 publications

References 105 publications

Functional and computed tomographic evolution and survival of restrictive allograft syndrome after lung transplantation

Functional and computed tomographic evolution and survival of restrictive allograft syndrome after lung transplantation

Bronchiolitis obliterans after allo-SCT: clinical criteria and treatment options

Transcript Signatures of Lymphocytic Bronchitis in Lung Allograft Biopsy Specimens

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