Bronchiolitis obliterans syndrome in single lung transplant recipients—patients with emphysema versus patients with idiopathic pulmonary fibrosis

Haider, Yussef; Yonan, Nizar; Moğulkoç, Nesrin; Carroll, K. B.; Egan, Jim

doi:10.1016/s1053-2498(01)00398-9

Cited by 26 publications

(17 citation statements)

References 12 publications

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“…This expands on the findings in a previously studied, small cohort of recipients with COPD (n ϭ 10) and IPF (n ϭ 6) with BOS (17). These investigators suggested a survival benefit in SLT recipients with a pretransplant diagnosis of COPD.…”

Section: Discussionsupporting

confidence: 75%

“…Clinical risk factors, such as type of transplantation, gender, and pretransplant diagnosis, have been demonstrated to influence various post-lung transplantation outcomes, such as survival, time-toonset of BOS, and functional status (14)(15)(16)(17). However, the impact of these important variables on course of FEV 1 after BOS onset had not been previously described.…”

Section: Discussionmentioning

confidence: 99%

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Course of FEV₁after Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients

Lama¹,

Murray²,

Lonigro³

et al. 2007

Am J Respir Crit Care Med

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Lung transplantation is the only viable option for many patients with chronic, end-stage lung diseases. However, 60% of patients within 5 years of transplant develop bronchiolitis obliterans syndrome (BOS) (1-4), a disease syndrome defined as a fall in FEV 1 of greater than 20% from baseline determined by the average of two measurements made at least 3 weeks apart (5). Median survival after onset of BOS is 3 to 4 years, with a range of 0 to 9.4 years (6-8). These survival numbers are comparable to other chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF). Similarly, although development of BOS is associated with progressive worsening of lung function, the rate of decline in FEV 1 after onset of BOS is believed to be variable among patients and over time (9). Although significant effort has been What This Study Adds to the FieldRapid onset of BOS, female gender, pretransplant diagnosis of idiopathic pulmonary fibrosis, and single-lung transplantation are associated with worse pulmonary function after BOS onset.made to understand factors associated with the risk of development of BOS, little information has been published regarding the course of FEV 1 after onset of BOS and the effect of various variables on it. This information is important for patient counseling and management, but is also crucial for designing diagnostic and therapeutic clinical trials in the field of BOS.The objectives of this study were to characterize the course of FEV 1 over time after development of BOS, to describe the natural history of spirometric dysfunction, and to determine the predictors that influence the rate of functional decline of FEV 1 in a large cohort of well-characterized lung transplant recipients.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Course of FEV₁after Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients

Lama¹,

Murray²,

Lonigro³

et al. 2007

Am J Respir Crit Care Med

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“…Survival at 5 yrs after the onset of BOS is only 30-40%, and survival at 5 yrs after transplantation is 20-40% lower in patients with than in patients without BOS [7]; this difference widens as postoperative follow-up increases. After single LTx, survival after BOS onset is longer in recipients with emphysema compared with recipients with idiopathic pulmonary fibrosis [8].…”

mentioning

confidence: 94%

Post-transplant bronchiolitis obliterans

Boehler

Estenne²

2003

Eur Respir J

179

105

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Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. However, chronic allograft dysfunction in the form of bronchiolitis obliterans remains a major hurdle that threatens both the quality of life and long-term survival of the recipients. It affects up to 50-60% of patients who survive 5 yrs after surgery, and it accounts for w30% of all deaths occurring after the third postoperative year.This article discusses the alloimmune-dependent and -independent risk factors for bronchiolitis obliterans, the current understanding of the pathogenesis of bronchiolitis obliterans based on results of animal and human studies, the clinical staging of the complication, strategies that may contribute to the prevention and/or early detection of bronchiolitis obliterans, and suggestions for future research.

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“…Bronchiolitis obliterans is a form of rejection to lung transplantation [8]. The fibrotic involution of our patient's transplanted lung should be probably related to the end stage of this complication.…”

Section: Discussionmentioning

confidence: 74%

Re-activation of IPF and Appearance of Cancer on the Native Lung after Single Lung Transplantation

Scioscio¹

2013

OMICS J Radiology

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Bronchiolitis obliterans syndrome in single lung transplant recipients—patients with emphysema versus patients with idiopathic pulmonary fibrosis

Cited by 26 publications

References 12 publications

Course of FEV₁after Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients

Course of FEV₁after Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients

Post-transplant bronchiolitis obliterans

Re-activation of IPF and Appearance of Cancer on the Native Lung after Single Lung Transplantation

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Bronchiolitis obliterans syndrome in single lung transplant recipients—patients with emphysema versus patients with idiopathic pulmonary fibrosis

Cited by 26 publications

References 12 publications

Course of FEV1after Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients

Course of FEV1after Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients

Post-transplant bronchiolitis obliterans

Re-activation of IPF and Appearance of Cancer on the Native Lung after Single Lung Transplantation

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Course of FEV₁after Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients

Course of FEV₁after Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients