Bronchoalveolar lavage and esophageal pH monitoring data in children with ?difficult to treat? respiratory symptoms

Sacco, Oliviero; Fregonese, B; Silvestri, Michela; Sabatini, Federica; Mattioli, Girolamo; Rossi, Giovanni A.

doi:10.1002/1099-0496(200010)30:4<313::aid-ppul7>3.0.co;2-h

Cited by 69 publications

(59 citation statements)

References 21 publications

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“…Thirtee of 50 patients had previously undergone EGDS + biopsies, which showed signs of esophagitis in 7. Six patients had previously undergone FBS + BAL, 3 with a pathologic lipid index [22].…”

Section: Patientsmentioning

confidence: 99%

Esophageal Impedance/pH Monitoring in Pediatric Patients: Preliminary Experience with 50 Cases

et al. 2006

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This paper describes multiple intraluminal impedance (MII) in 50 children with typical and atypical gastroesophageal reflux (GER) symptoms and discusses the possible clinical significance of objective numeric data provided by MII computed analysis. Patients underwent 24-hr pH/MII monitoring. Reflux parameters were analyzed with relation to age and reported symptoms. Nonacidic MII events occurred as frequently as acidic ones. A Pathologic Bolus Exposure Index associated with a normal pH Reflux Index was detected in 26% of our series. Significant correlations were found regarding acid and bolus clearing times and their ratio. We conclude that the low rate of symptom occurrence in the pediatric population represents a limit on MII evaluation. Our study confirmed that nonacid GER is at least as frequent as acid GER. As MII provides interesting objective data that could be used in clinical practice, we suggest further research to define normal ranges in the pediatric population.

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Section: Patientsmentioning

confidence: 99%

Esophageal Impedance/pH Monitoring in Pediatric Patients: Preliminary Experience with 50 Cases

et al. 2006

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“…Bronchoalveolor lavage was used to assess the presence of neutrophils in the airways and lipid-laden alveolar macrophages, and to demonstrate aspiration events [26]. Thoracic computed tomography (CT) scan was performed in selected cases with focal disorders to exclude congenital anomalies, bronchiectasis, or other mediastinal or lung disorders.…”

Section: Methodsmentioning

confidence: 99%

Outcome of laparoscopic Nissen?Rossetti fundoplication in children with gastroesophageal reflux disease and supraesophageal symptoms

et al. 2004

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“…Three prospective studies attempting to compare LLMI values in children with chronic respiratory symptoms with and without documented GOR [52][53][54] have shown even wider variability than studies for direct aspiration (table 2) [ [42][43][44]. The most striking limitation of these studies is study design.…”

Section: Flexible Bronchoscopy With Balmentioning

confidence: 99%

Advances in the diagnosis and management of chronic pulmonary aspiration in children

et al. 2006

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Chronic pulmonary aspiration (CPA) in children is an important cause of recurrent pneumonia, progressive lung injury, respiratory disability and death. It is sporadic, intermittent and variable, and often occurs in children with complicated underlying medical conditions and syndromes that produce symptoms indistinguishable from CPA. For most types of aspiration there is no gold-standard diagnostic test. The diagnosis of CPA is currently made clinically with some supporting diagnostic evaluations, but often not until significant lung injury has been sustained. Despite multiple diagnostic techniques, the diagnosis or exclusion of CPA in children is challenging. This is of particular concern given the outcome of unrecognised progressive lung injury and the invasiveness of definitive therapies.Although new techniques have been introduced since the 1990s and significant advances in the understanding of dysphagia and gastro-oesophageal reflux have been made, characterisation of the aspirating child remains elusive.

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Bronchoalveolar lavage and esophageal pH monitoring data in children with ?difficult to treat? respiratory symptoms

Cited by 69 publications

References 21 publications

Esophageal Impedance/pH Monitoring in Pediatric Patients: Preliminary Experience with 50 Cases

Esophageal Impedance/pH Monitoring in Pediatric Patients: Preliminary Experience with 50 Cases

Outcome of laparoscopic Nissen?Rossetti fundoplication in children with gastroesophageal reflux disease and supraesophageal symptoms

Advances in the diagnosis and management of chronic pulmonary aspiration in children

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