Bronchoalveolar Lavage in Acquired Immunodeficiency Syndrome

Demonstration of defective C3-receptor-mediated clearance by the reticuloendothelial system in patients with acquired immunodeficiency syndrome.

“…First, they have decreased numbers of pulmonary macrophages obtained by bronchoalveolar lavage (13,14). Microscopic examination of peripheral white blood cells has revealed decreased percent representation and absolute numbers of peripheral blood monocytes (15,16), the presence of large atypical peripheral blood monocytes with a fine nuclear chromatin, and one or more cytoplasmic vacuoles (16).…”

“…have demonstrated decreased numbers of monocytes and macrophages (13)(14)(15)(16), the presence of atypical peripheral blood monocytes (16), impaired chemotaxis (15,17), defective phagocytosis (17), abnormal secretion of interleukin-l (18), and impaired monocyte help for the in vitro proliferative response of lymphocytes (19). We have also demonstrated in vivo that Fc-receptor-specific function of the reticuloendothelial system (RES) in patients with AIDS is abnormal, as shown by defective clearance from the circulation of IgG-sensitized autologous erythrocytes (20).…”

“…Moreover, macrophages cultured from the brain or lung of patients with AIDS were found to harbor HIV (12). In addition, it has been well documented that there is monocyte-macrophage dysfunction in AIDS (13)(14)(15)(16)(17)(18)(19)(20)(21).…”

Role of Cytology and Polymerase Chain Reaction Based Detection of Pneumocystis jirovecii Infection in Bronchoalveolar Lavage Fluid

“…Elevated levels of neutrophils and lymphocyte counts in BALF cell population have been reported in patients with AIDS with PCP, possibly leading to fatal outcomes. 7,8 In view of this, our experience in the analysis of inflammatory cell populations in BALF cytology, PCR detection of P jirovecii from cytology slide scrapings and its use in stepwise application of molecular diagnostic modalities of PCP is presented in this paper.…”

Early experience and difficulties with bronchoalveolar lavage and transbronchial biopsy in the diagnosis of AIDS associated pneumonia in Britain.

“…3 Bronchoalveolar lavage has been used to obtain diagnostic material in suspected opportunistic chest infection, both in iatrogenically immunosuppressed patients4 and in patients with AIDS. 5 We present our findings from bronchoalveolar lavage and transbronchial biopsy in the first five patients with AIDS associated pneumonia seen at the Middlesex Hospital.…”