Bronchoalveolar lavage in mixed cryoglobulinaemia associated with hepatitis C virus

Manganelli, P; Salaffi, Fausto; Subiaco, S; Carotti, Marina; Cervini, C; Consigli, G.F.; Majori, Maria; Pesci, Alberto

doi:10.1093/rheumatology/35.10.978

Cited by 29 publications

(8 citation statements)

References 25 publications

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“…Lung involvement in CV is mainly characterized by subclinical alveolitis, which occasionally leads to interstitial lung fibrosis [9,29]. Although only scarce data are available in the literature, patent pulmonary involvement has been associated with poor survival in patients with CV [28].…”

Section: Reviewmentioning

confidence: 99%

Vasculitic emergencies in the intensive care unit: a special focus on cryoglobulinemic vasculitis

Zaidan

Mariotte

Galicier

et al. 2012

Ann. Intensive Care

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Vasculitis is characterized by the infiltration of vessel walls by inflammatory leukocytes with reactive damage and subsequent loss of vessel integrity. The clinical course of systemic vasculitis may be punctuated by acute life-threatening manifestations that require intensive care unit (ICU) admission. Furthermore, the diagnosis may be established in the ICU after admission for a severe inaugural symptom, mostly acute respiratory failure. Among the systemic vasculitides, cryoglobulinemic vasculitis (CV) has been rarely studied in an ICU setting. Severe CV-related complications may involve the kidneys, lungs, heart, gut, and/or central nervous system. The diagnosis of CV in the ICU may be delayed or completely unrecognized. A high level of suspicion is critical to obtain a timely and accurate diagnosis and to initiate appropriate treatment. We describe severe acute manifestations of CV based on six selected patients admitted to our ICU. That all six patients survived suggests the benefit of prompt ICU admission of patients with severe CV.

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Section: Reviewmentioning

confidence: 99%

Vasculitic emergencies in the intensive care unit: a special focus on cryoglobulinemic vasculitis

Zaidan

Mariotte

Galicier

et al. 2012

Ann. Intensive Care

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“…This lung inflammation is subclinical and does not predict any lesion of the pulmonary function [37].…”

Section: Respiratory Manifestations Of Cryoglobulinaemiamentioning

confidence: 83%

A revision on cryoglobulinaemia associated to neoplastic diseases

Molina‐Garrido

Guillén‐Ponce

2007

Clin Transl Oncol

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Cryoglobulinaemia is an infrequent process and has been classified in types I, II and III. Type I corresponds to monoclonal cryoglobulinaemia; types II and III are comprised in the group of mixed cryoglobulinaemias (MC). In MC type II, cryoglobulinaemias are made up of a monoclonal rheumatoid factor vs. a polyclonal IgG. In MC type III all compounds are polyclonal. Monoclonal cryoglobulinaemias are usually associated to malignant haematological processes, while MC are associated to systemic diseases and infection. More research is needed on the natural history, causes, treatment and evolution of cryoglobulinaemia. This revision analyses a more recent knowledge on this entity, as well as its association to neoplastic diseases.

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“…This rheumatoid factor would form giant immune complexes directly with HCV particles and anti-HCV IgG. Otherwise, bronchoalveolar lavage shows a subclinical T-lymphocytic alveolitis in patients with HCV-related mixed cryoglobulinemia [12]. Therefore, the recidivant course could be related to an intense activation of B-lymphocytes, with more substrate to form immune complexes and resistance to immunosuppressive drugs.…”

Section: Discussionmentioning

confidence: 99%

Diffuse recidivant alveolar hemorrhage in a patient with hepatitis C virus-related mixed cryoglobulinemia

Gómez-Tello

Oñoro-Cañaveral

Monje

et al. 1999

Intensive Care Medicine

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A case of diffuse and recidivant alveolar hemorrhage is presented in a patient with hepatitis C virus-related type II mixed cryoglobulinemia with membranoproliferative glomerulonephritis. The patient was a 48-year-old white woman who suffered several outbreaks of pulmonary hemorrhage refractory to treatment with steroids, cyclophosphamide, azathioprine, plasmapheresis and interferon-alpha. The patient also presented persistent increased titers of immune complexes and rheumatoid factor with no histological hepatic alterations. Some considerations about evolution and treatment are given according to the updated physiopathology of this disease.

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Bronchoalveolar lavage in mixed cryoglobulinaemia associated with hepatitis C virus

Cited by 29 publications

References 25 publications

Vasculitic emergencies in the intensive care unit: a special focus on cryoglobulinemic vasculitis

Vasculitic emergencies in the intensive care unit: a special focus on cryoglobulinemic vasculitis

A revision on cryoglobulinaemia associated to neoplastic diseases

Diffuse recidivant alveolar hemorrhage in a patient with hepatitis C virus-related mixed cryoglobulinemia

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