Bronchoalveoläre Lavage bei Haarzellleukämie mit Lungeninfiltration

Hansen, Torsten; Constantin, C.; Weber, Matthias; Titze, Ulf; Hartmann, Fritz

doi:10.1007/s00292-019-0586-3

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…After excluding the lung infection, the therapy was completed with a cladribine regimen. The authors observed regression of pulmonary involvement upon successful completion of the treatment 6 . The authors from the USA published a similar case report in 1982 (ref.…”

Section: Discussionmentioning

confidence: 95%

Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report

Ecsiova¹,

Kamarádová²,

Nová³

et al. 2023

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disease with an accumulation of mature B lymphocytes with fine reticular chromatin and cytoplasm with typical hairy-like cytoplasmic projections. Rarely, hairy cell leukemia manifests as a lung infiltration. The differential diagnosis between infection and malignant involvement with hairy cell leukemia is often challenging in such situations. Methods and Results. We present a 53-year-old female with an uncommon pulmonary involvement with hairy cell leukemia. In addition, we discuss the complicated differential diagnosis of pulmonary disease in patients with hairy cell leukemia and the treatment approach to these patients. Conclusion. This case report describes the successful therapy management of a patient with pulmonary involvement by hairy cell leukemia. Therapy with interferon-alfa and cladribine resulted in long-term remission of the underlying disease.

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Section: Discussionmentioning

confidence: 95%

Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report

Ecsiova¹,

Kamarádová²,

Nová³

et al. 2023

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…On the one hand, performing bronchoscopy and related treatment can not only aspirate deep sputum on the basis of detailed observation of the lesions, and then the deep sputum can be collected for bacterial culture and drug susceptibility testing, which is conducive to the clinical selection of antibiotics. Implementing BAL can also remove the causes of lumen blockage, such as phlegm deposits, to achieve the objective of adequate drainage (13). On the other hand, the method of using bronchoscopy makes it possible to operate under direct vision, which can avoid or reduce damage of the tracheal mucosa, and can quickly improve the hypoxic state in a short time.…”

Section: Discussionmentioning

confidence: 99%

Effect of bronchoalveolar lavage on the clinical efficacy, inflammatory factors, and immune function in the treatment of refractory pneumonia in children

et al. 2021

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Background: Refractory pneumonia is a special type of pneumonia in children. This study aimed to analyze the effect of bronchoalveolar lavage (BAL) on the clinical efficacy, inflammatory factors, and immune function in the treatment of pediatric refractory pneumonia.Methods: A total of 196 children with refractory pneumonia admitted to our hospital from January 2017 to January 2020 were enrolled and allocated to a study group (n=99) and a control group (n=97). The study group was treated with BAL treatment plus conventional treatment, and the control group was treated with conventional treatment. The clinical efficacy, time of fever regression, time of cough relief, and length of hospital stay were compared between groups. Changes in inflammatory factors, immune function, pulmonary ventilation function, and complications were analyzed. The levels of inflammatory factors in BAL fluid were compared.Results: The times of fever remission, cough relief, and hospital stay of the study group was shorter than those of the control group, and the total clinical effective rate of the study group was higher. At any time after treatment, the levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factoralpha (TNF-α) in the study group were lower than the control group. After 3-day of treatment, IL-6, CRP and TNF-α in BAL fluid in the study group were significantly decreased compared with before treatment.Immunoglobulin A (IgA) and immunoglobulin G (IgG) levels in the study group were higher than those in the control group at any time after treatment, and immunoglobulin M (IgM) levels were lower than in the control group. The levels of oxygenation index (OI), lung dynamic compliance (Cdyn), and work of breathing (WOB) in the study group were higher than those in the control group at any time after treatment.Conclusions: BAL treatment can effectively relieve the inflammatory response, improve immune function and lung ventilation function in children with refractory pneumonia. The clinical effect is remarkable and worthy of promotion.

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Bronchoalveoläre Lavage bei Haarzellleukämie mit Lungeninfiltration

Cited by 2 publications

References 9 publications

Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report

Pulmonary damage in a patient with hairy cell leukemia - infectious involvement or hematological disease activity? Case report

Effect of bronchoalveolar lavage on the clinical efficacy, inflammatory factors, and immune function in the treatment of refractory pneumonia in children

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