Bronchogenic carcinoma in lung transplant recipients

Administration of anti-neoplastic agents to treat malignancies in solid organ transplant recipients

“…In the past, case reports have described experiences with treatment of non-small cell lung cancer in post-SOT patients, the difficulties associated with administering chemotherapy (cisplatin and vinblastine in one patient and carboplatin and paclitaxel in another patient), and complications including diarrhea, neutropenic fever and sepsis [16,17] . In a previous study which involved 5 children who had liver or heart transplantation for primary malignancies, the children received various chemotherapy agents (adriamycin, cyclophosphamide, ifosfamide, etc.)…”

Single-lung Transplant Complicated by Unexpected Explant Carcinoma: A Management Dilemma

“…We were guided by the lack of absolute evidence for the management of native-lung tumors in the face of immunosuppression to a course of management that we knew exposed our patient to significant risk. [5][6][7][8] Serial CT follow-up, however short the interval time, is unlikely to detect carcinoma until it has become well developed. The aim of follow-up should be to detect and intervene before spread has occurred to N2 nodal stations.…”

“…[5][6][7][8] However, Abrahams and colleagues reported 4 instances of explantedlung carcinoma in 214 lung transplant recipients. 9 The majority of the tumors reported in lung explants are Stage 1 adenocarcinomas.…”

Small-cell Lung Carcinoma of Recipient Origin After Bilateral Lung Transplantation For Cystic Fibrosis

“…18 The histologic type is more frequently adenocarcinoma. Relapse of the carcinoma after transplantation has been described even when the initial tumor was of a less-advanced stage, 13,15 but complete remission is possible. 18,21,22 In a study of 43 bronchogenic carcinomas incidentally diagnosed in explanted lungs, the 5-year actuarial survival was 51% in the 22 Stage I patients.…”

“…1,7,8 Bronchial carcinomas have been reported during thoracic transplantation, initially in cardiac transplantation, 9 -12 then in lung transplantation. [13][14][15][16][17][18] Their incidence could represent approximately of 2% of lung transplants, 13 which might be much higher compared with the incidence of bronchial carcinoma in other organ transplant recipients. 19 In heart and/or lung transplantation, non-small-cell bronchial carcinoma arises in most cases in the native lung as a consequence of tobacco exposure and other carcinogenic conditions, such as pulmonary fibrosis.…”