Bronchoscopic diagnosis of pulmonary coccidioidomycosis comparison of cytology, culture, and transbronchial biopsy

DiTomasso, John P.; Ampel, Neil M.; Sobonya, Richard E.; Bloom, John W.

doi:10.1016/0732-8893(94)90070-1

Cited by 59 publications

(28 citation statements)

References 20 publications

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“…The severity of pulmonary infection is associated with the status of immunosuppression. Diagnosis can be made in BAL, but tissue examination is often needed [62]. …”

Section: Fungal Infectionsmentioning

confidence: 99%

The Lung in the Immunocompromised Patient

Tamm

1999

Respiration

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Pulmonary infections decisively contribute to morbidity and mortality in immunocompromised patients. Bacterial, mycobacterial and infections with Pneumocystis carinii have been reviewed in an article in the last issue of Respiration. In this review, viral and fungal pulmonary infections are discussed in HIV-positive patients and in patients treated with high-dose chemotherapy, stem cell or solid-organ transplantation.

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“…The severity of pulmonary infection is associated with the status of immunosuppression. Diagnosis can be made in BAL, but tissue examination is often needed [62]. …”

Section: Fungal Infectionsmentioning

confidence: 99%

The Lung in the Immunocompromised Patient

Tamm

1999

Respiration

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“…Therefore we performed bronchoscopy again in an attempt to elucidate the origin of the fungus ball in the cavity. DiTomasso et al reported that cytological examination alone detected C. immitis in only 35% of the patients whose bronchial wash had already grown C. immitis (7). Also in the present case, culturing of the sample was necessary to identify C. immitis.…”

Section: Discussionmentioning

confidence: 71%

Pulmonary Coccidioidomycosis That Formed a Fungus Ball with 8-years Duration

et al. 2005

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Coccidioidomycosis, caused by inhaling Coccidioides immitis, is a mycosis imported from endemic regions including the southwestern United States. C. immitis is so virulent that even a short-term stay in the endemic area can provide a chance for infection. Here, we report a 33-year-old Japanese man with formation of a fungus ball inside the pulmonary cavity secondary to coccidioidomycosis with a duration of 8 years, which is considered rare. He was infected with C. immitis in the United States in 1996. A nodule remained in the lung, which later cavitated with fungus ball formation. We identified Coccidioides immitis in the cultured specimen from the cavity and serum antibodies against it. We performed a lobectomy in 2003 since anti-fungal treatment was only temporarily effective. He is still free of disease 6 months later. (Internal Medicine 44: 141-144, 2005)

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“…Direct identification of the characteristic spherules from sputum, bronchial washing, BAL, and tissues by potassium hydroxide, cytologic preparation, or special stains is the most rapid way to confirm the diagnosis. Unfortunately, the sensitivity of direct microscopic studies of sputum samples, bronchial washing, or BAL is low, ranging from 10% to 40% [17,18]. However, cultures from these specimens are reportedly more sensitive, especially samples from patients with chronic progressive pneumonia [13].…”

Section: Diagnosismentioning

confidence: 96%

Coccidioidomycosis pulmonary infection

Lin

Hamill

2001

Curr Infect Dis Rep

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Disease caused by Coccidioides immitis has increased in frequency in recent years because of marked population shifts into highly endemic areas, as well as perturbations of the environment caused by construction, agricultural, and natural activities. Because disease may occur in persons in locations outside of the endemic regions, practitioners must be aware of the possibility of infection in those who may have traveled or resided in areas of risk. Recently, advances in laboratory methods have facilitated diagnosis of coccidioidomycosis, and information about therapies that are easier to administer has become available. Challenges in the management of this infection still remain, particularly with regard to more reliable antifungal drugs and protective vaccines.

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Bronchoscopic diagnosis of pulmonary coccidioidomycosis comparison of cytology, culture, and transbronchial biopsy

Cited by 59 publications

References 20 publications

The Lung in the Immunocompromised Patient

The Lung in the Immunocompromised Patient

Pulmonary Coccidioidomycosis That Formed a Fungus Ball with 8-years Duration

Coccidioidomycosis pulmonary infection

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