Bronchospasm potentiating effect of methanolic extract of Ficus religiosa fruits in guinea pigs

Ahuja, Deepti; Bijjem, Krishna Reddy V.; Kalia, Ajudhia Nath

doi:10.1016/j.jep.2010.09.023

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…In the mast cell stabilizing model, the aqueous extract of Ficus religiosa leaves at 10, 20 and 30 μg/ml significantly increase the number of intact cells [117].However, in another study, the administration of methanolic extract of Ficus religiosa fruits (125, 250 and 500 mg/kg, po) did not produced any significant effect on latency to develop histamine induced pre-convulsive dyspnea. While, in a dose of (0.5, 1 and 2 mg/ml), it possessed significant potentiation of the bronchoconstriction induced by both histamine and acetylcholine on guinea pig tracheal chain preparation [75].…”

Section: Effect On Asthmamentioning

confidence: 91%

Pharmacology of Ficus religiosa- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Chemical analysis showed that Ficus religiosa contained tannins, phenols, saponins, sugars, alkaloids, methionine, terpenoids, flavonoids, glycosides, proteins, separated amino acids, essential and volatile oils and steroids. Previous pharmacological studies revealed that Ficus religiosa possessed antimicrobial, anti-parasitic, anti-Parkinson's, anticonvulsant, anti-amnesic, anticholinergic, antidiabetic, antiinflammatory, analgesic, cytotoxic, anti-ulcer, wound healing, antioxidant, anti-asthmatic, reproductive, hepato-, nephro-and dermato-protective effects. The current review highlights the chemical constituents and pharmacological effects of Ficus religiosa.

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Section: Effect On Asthmamentioning

confidence: 91%

Pharmacology of Ficus religiosa- A review

Al-Snafi¹

2017

IOSRPHR

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“…Fruits containing bioactive compounds such as Terpenoids, glycosides, flavonoids, serotonergic content. The animal study Methanolic extract of fruits (0.5, 1 and 2 mg/ kg of body weight) showed significant effects in histamine and acetylcholine induced guinea pig and the mechanism of action shows the Significantly potentiated the EC (50) doses of both histamine and acetylcholine [56].…”

Section: Review Of Literaturementioning

confidence: 98%

A Review on Ficus Religiosa Moraceae: Distribution, Traditional Uses and Pharmacological Properties

Kumari¹,

Prajaptai²,

Jangir

et al. 2022

JBPR

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Medicinal plants play a vital role in improving the health of people. Hundreds of medicinal plants have been used to cure various diseases since ancient times. Ficus religiosa (Peepal) has an important place among herbal plants. Almost every part of this tree i.e., leaves, bark, seeds, and fruits are used in the preparation of herbal medicines. Ficus religiosa is grown by specialty tree plant nurseries for use as an ornamental tree, in gardens and parks in tropical and subtropical climates. Peepul trees are native to Indian subcontinent and thrive in hot, humid weather. They prefer full sunlight and can grow in all soil types, though loam is the best. When planting, use soil with a pH of 7 or below. It is native to the Asia-Tropical (Bangladesh; India, Nepal, Pakistan, China, Myanmar, Thailand, Vietnam, and Iraq) and it is cultivated in wide tropical areas. Peepal is a large, fast-growing deciduous tree. It has a heart-shaped leaf. It is a medium size tree and has a large crown with wonderful wide-spreading branches. The fruits of the Peepal are hidden with the figs. It has fast-growing nature, tolerance to various climate zones and soil types, reported lifespan of over 3,000 years, and its suffocating growth habit as it often begins life as an epiphyte. Different parts of plants have been used in the Indian traditional system of medicine such as: Anti-diabetic, Anti-inflammatory, Antioxidant, Analgesic, Anticonvulsant, Antimicrobial, Wound healing, Anti-amnesic, Anti-fertility, Anti-ulcer, Anti-Parkinson, Anti-asthmatic, Kidney-protective, Toothache and Eye ache.

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“…The use of the guinea pig model for preclinical studies of asthma and chronic obstructive pulmonary disease (COPD) is increasingly popular due to the fact that the animal seldom bites and its allergen-induced bronchoconstriction and that of human bronchial asthma are similar (Canning and Chou, 2008;Hong and Chang, 2008). It is a widely accepted method to use the guinea pig tracheal chain preparation as an in vitro model to evaluate the potency of plant extracts or compounds having bronchodilatory effect (Ahuja et al, 2011).…”

Section: Guinea Pig Tracheal Smooth Muscle Relaxationmentioning

confidence: 99%