Pharmacology of Ficus religiosa- A review

Al-Snafi, Ali Esmail

doi:10.9790/3013-0703014960

Cited by 27 publications

(26 citation statements)

References 52 publications

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“…The chemical constituents which were analyzed in this study consist of terpenoid, alkaloid, and flavonoid. Those consistent with previous phytochemical analysis [26], [27], [28]. F. religiosa is already known to have multiple biological activities and is famous in herbal medicine.…”

Section: Pharmacokinetic and Anti-inflammatory Scoresupporting

confidence: 91%

“…F. religiosa is already known to have multiple biological activities and is famous in herbal medicine. It was noted to reveal several pharmacological activities such as antidiabetic, anti-inflammatory, antioxidant, antimicrobial, analgesic, and anticonvulsant activity [26], [27], [28], [29]. By the molecular docking method, the ability of the ligand to bind to the macromolecule will be revealed by the binding affinity result [19].…”

Section: Pharmacokinetic and Anti-inflammatory Scorementioning

confidence: 99%

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Molecular Docking Analysis of Ficus religiosa Active Compound with Anti-Inflammatory Activity by Targeting Tumour Necrosis Factor Alpha and Vascular Endothelial Growth Factor Receptor in Diabetic Wound Healing

Yueniwati

Syaban

Erwan

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Diabetes mellitus contributes to the delayed healing of wounds causes disturbance of inflammatory cytokine. Tumour necrosis factor alpha (TNF-alpha) and Vascular Endothelial Growth Factor Receptor (VEGFR) both have a role in the persistent inflammation associated with diabetic wounds. Ficus religiosa has developed a reputation as a traditional wound healer among some java people in Indonesia. AIM: Our study aims to discover the molecular interaction between the active constituents of F. religiosa with TNF-alpha and VEGFR. MATERIALS AND METHODS: This research was conducted in computerized molecular docking using Protein database, Pymol, Discovery studio, and Pyrex software. A thorough literature search was conducted to identify the potential compound and molecular target for diabetic wounds. Analysis of its anti-inflammatory properties was also carried out using a passonline webserver. Pharmacokinetic analysis was performed using the Lipinski Rule of Five websites and the PreADMET website. RESULTS: Each of the study’s active compounds has a good pharmacokinetic profile. The predictions of the compound’s structure indicate that it has a strong anti-inflammatory impact. Lupenyl acetate and Lanosterol bind more strongly to the TNF-alpha than the natural ligand, but Piperine binds more strongly to VEGFR. CONCLUSIONS: Lupenyl acetate, Lanosterol, and Piperine compounds have anti-inflammatory effects through inhibition of TNF-alpha and VEGFR. In addition, this compound has potential to become a drug because it has good pharmacokinetics. Future studies are required to determine the effectiveness and toxicity of Lupenyl acetate, Lanosterol, and Piperine as potential treatment in diabetic wounds.

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Section: Pharmacokinetic and Anti-inflammatory Scoresupporting

confidence: 91%

Section: Pharmacokinetic and Anti-inflammatory Scorementioning

confidence: 99%

Molecular Docking Analysis of Ficus religiosa Active Compound with Anti-Inflammatory Activity by Targeting Tumour Necrosis Factor Alpha and Vascular Endothelial Growth Factor Receptor in Diabetic Wound Healing

Yueniwati

Syaban

Erwan

et al. 2021

Open Access Maced J Med Sci

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“…Moraceae) also known as Peepal tree in hindi, Asvatthah in Sanskrit and sacred fig in Bengali has traditional pharmacological effects of antimicrobial, anti-parasitic, anti-Parkinson's, anticonvulsant, anti-amnesic, anticholinergic, antidiabetic, anti-inflammatory, analgesic, cytotoxic, anti-ulcer, wound healing, antioxidant, anti-asthmatic, reproductive, hepato-, nephro-and dermato-protective. Plant secondary metabolites such as phytosterols, flavonoids, glucosides and furano-coumarin derivatives are the different active compounds present in different parts of this plant [7][8][9][10][11]. Syzygium cumini (SC), (Fam.…”

Section: Introductionmentioning

confidence: 99%

“…Plant secondary metabolites (PSM) have a wide range of pharmacological actions [7][8][9][10][11][12][13][14][15]. These PSMs have nutraceutical potentialities and being of plant origin are phytonutraceuticals.…”

Section: Introductionmentioning

confidence: 99%

Development of a standardized combined plant extract containing nutraceutical formulation ameliorating metabolic syndrome components

De¹,

Bhandari

Katakam³

et al. 2019

SN Appl. Sci.

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Plant bioactives have a great role in combating multifactorial disease conditions like metabolic syndrome (MetS). This research work aims to develop a standardized plant extract combination and formulate it to tablets with nutraceutical potentials. The extract was prepared from the bark powder of Ficus religiosa, seed powder of Syzigium cumini and leaf powder of Ocimum bacilicum chemometrically optimized in the ratio of 1.15:1.15:1.68 (Ashwattha: Jamun: Basil or FR: SC: OB). It is enriched in screened and pharmacologically active plant secondary metabolites. The tablets were prepared by direct compression using single-punch tablet machines. The nutraceutical tablets passed all the prescribed quality control tests with a justified pharmacokinetic profile. Results of animal experimentations have shown the hypoglycemic, hypolipidemic effect and antihypertensive effect of the nutraceutical tablets in relevant animal models. Thus, the nutraceutical formulation that showed effectivity in combating MetS can be opted as an adjunct therapy.

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“…Many medicinal plants can atenuae the toxicit of bleomycin, methotrexate, cisplatin, mitomycin-C, urethane, cyclophosphamide and many other cyotoxic drugs [6][7][8][9][10]. These plants included: Achillea santolina [11], Alpinia galangal [12], Althaea officinalis [13], Anchusa strigosa [14], Anethum graveolens [15], Astragalus hamosus [16], Bauhinia variegate [17], Brassica rapa [18,19], Caesalpinia crista [20], Cassia occidentalis [21], Cichorium intybus MATERIALS AND METHODS [22], Calotropis procera [23], Crocus sativus [24], Ficus cunia [25] and Ficus religiosa [26]. Carthamus tinctorius contained oils, proteins, minerals, phenolics, flavonoids, alkaloids, lignans, carboxylic acids, steroids, polysaccharides, quinochalcone C-glycosides and quinonecontaining chalcones.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of the Carthmus Tinctorius Leaves Extracton Methotrexate-Induced Pulmonary Fibrosis in Rats

Khadhem¹,

Mthuwaini²,

Majid³

2019

Int J Curr Pharm Sci

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Objective: Pulmonary fibrosis (PF) is an irreversible and untreatable human disease encompasses a large group of chronic lung disorders associated with excessive remodeling, scarring, and fibrosis.The current work was designed to study the harmful effects of methotrexate (MTX) administration on the lung and the possible protective role of Carthmus tinctorius leaves extract. The animals were utilized in this study. Methods:A total of 40 male healthy adult Wistar albino rats with anaverage body weight of 200±25 g, were divided into four groups (10 animals each). G1: control group, G2: MTX group, G3: Carthamus tinctorius (CT), group G4:MTX+Carthamus tinctorius(CT). CT was administered orally at a dose of (40 mg/kg/day) for 4 w to G3 and G4. The (CT) group were performed to explore any toxic effect of the (CT) extract on the lung. Rats of G2 and G4 administered 4 mg/kg dose of MTX orally for 28 d. Rats of G1 were intraperitoneally (i. p) administered with normal saline 0.5 ml ∕ day for four weeks (4wk) to serveas control. The animals were weighed at the beginning, though, and at the end of experiments. Results:The study showed that the relative lung weight was significantly increased at (P˂0.0 1) in MTX-treated animals in comparison to the control group. A combination of CT extract with MTX revealed significant decrease (P<0.01) in the lung relative weight in comparison to MTX group. Histopathological examination revealed that lung injury was less severe in group 3 and 4compared to group 2. The results indicated that CT significantly decreased collagen deposition, hydroxyproline content, and ameliorated pathological changes. Conclusion:The study has clearly identified the importance protective role of CT extract on pulmonary fibrosis induced by methoxerate. We recommended CT as one of therapeutic strategy to amelioratethe lung fibrosis associated with methotrexate therapy.

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Pharmacology of Ficus religiosa- A review

Cited by 27 publications

References 52 publications

Molecular Docking Analysis of Ficus religiosa Active Compound with Anti-Inflammatory Activity by Targeting Tumour Necrosis Factor Alpha and Vascular Endothelial Growth Factor Receptor in Diabetic Wound Healing

Molecular Docking Analysis of Ficus religiosa Active Compound with Anti-Inflammatory Activity by Targeting Tumour Necrosis Factor Alpha and Vascular Endothelial Growth Factor Receptor in Diabetic Wound Healing

Development of a standardized combined plant extract containing nutraceutical formulation ameliorating metabolic syndrome components

The Protective Effect of the Carthmus Tinctorius Leaves Extracton Methotrexate-Induced Pulmonary Fibrosis in Rats

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