Brønsted Acidic Ionic Liquid–Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and Thiones Under Solvent-Free Conditions

Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

“…Aromatic and aliphatic aldehydes reacted easily to afford the corresponding 3,4dihydropyrimidin-2(1H)-ones and thiones under solvent-free conditions. 315 Pyrimidinone derivatives 358 have also been synthesized from the reaction of aromatic aldehydes 356, cyclopentanone 357, and urea or thiourea 140/215 in the presence of N-(4-sulfonic acid) butyl triethyl ammonium hydrogen sulfate([TEBSA][HSO4]) as the Brønsted acidic ionic liquid as well as an effective catalyst under thermal and solvent-free conditions (Scheme 106). 316 The one-pot synthesis of substituted pyrimidine derivatives from acetylenedicarboxylate, amine, and orthoformate has been developed recently by Reddy and Nagarajan.…”

Brønsted Acidic 1-Ethyl-1,2,4-Trizolium Phenylsulfonate as Catalyst for Biginelli Reaction

“…The DHPMs synthesis in environmental benign route is an outstanding area of research. The green chemistry is suitable for the above mentioned route and many green catalysts were used to synthesize DHPMs and the ionic liquids is one of them [6][7][8][9][10]. In Biginelli reaction, chemists used number of catalyst like metal salts such as LiBr, FeCl3/Si(OEt)4, Cu(OTf)2, CeCl3 [11][12][13][14][15][16][17][18].…”