Brown adipose tissue transplantation as a novel alternative to obesity treatment: a systematic review

Payab, Moloud; Abedi, Mina; Heravani, Najmeh Foroughi; Hadavandkhani, Mahdieh; Arabi, Maryam; Tayanloo-Beik, Akram; Hosseini, Marjan; Gerami, Hadis; Khatami, Fateme; Larijani, Bagher; Abdollahi, Mohammad; Arjmand, Babak

doi:10.1038/s41366-020-0616-5

Cited by 41 publications

(32 citation statements)

References 39 publications

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“…The BAT is a novel metabolic organ that governs glycolipid metabolism and plays important roles in the balance of energy (Harms & Seale, 2013; Payab et al., 2020; Vernochet et al., 2010; Wang et al., 2015). T2DM important phenotypes of metabolic syndrome were hyperglycemia and hyperlipidemia as a typical metabolic syndrome (Bensinger & Tontonoz, 2008).…”

Section: Discussionmentioning

confidence: 99%

Dietary low ratio of n‐6/n‐3 polyunsaturated fatty acids improve type 2 diabetes mellitus via activating brown adipose tissue in male mice

Hao

Liu

Zhang

et al. 2021

Journal of Food Science

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The ratio n‐6/n‐3 polyunsaturated fatty acids (PUFA) has been caused widespread discussion. However, the best ratio and mechanism of n‐6/n‐3 PUFA in type 2 diabetes mellitus (T2DM) are largely unknown. This study investigated the effects of different ratio of n‐6/n‐3 PUFA diets on brown adipose tissue (BAT) and T2DM in mice. Results showed that compared with high ratio of n‐6/n‐3 PUFA (50:1) diet, lower ratio of n‐6/n‐3 PUFA (1:1 and 5:1) diets significantly increased BAT mass by 67.55% and 60.49%, decreased the fasting blood glucose (24.87% and 20.64%), total cholesterol (32.9% and 23.84%), triglyceride (33.51% and 29.62%), low‐density lipoprotein cholesterol (19.23% and 17.38%), and increased glucose tolerance by 21.99% and 15.52%. Further, qRT‐PCR analyses indicated that lower ratio of n‐6/n‐3 PUFA diets activated BAT, increased the expression of Ucp1, β‐3AR, PPAR‐γ, cAMP, GLU1, HSL, LPL, and PGC‐1α, further improved lipid and glucose metabolism in T2DM mice. In conclusion, this study substantiated that the lower ratio of n‐6/n‐3 PUFA (1:1 and 5:1) improve symptoms associated with T2DM via activating BAT. Practical Application Dietary ratio of n‐6/n‐3 polyunsaturated fatty acids is essential for the improvement of chronic diseases. Our current study showed that 1:1 or 5:1 ratio of n‐6/n‐3 polyunsaturated fatty acids had better efficiency for type 2 diabetes mellitus via activating brown adipose tissue when compared with 1:50. This finding provided useful guidance for the daily diet of patients with diabetes.

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Section: Discussionmentioning

confidence: 99%

Dietary low ratio of n‐6/n‐3 polyunsaturated fatty acids improve type 2 diabetes mellitus via activating brown adipose tissue in male mice

Hao

Liu

Zhang

et al. 2021

Journal of Food Science

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“…The crosstalk between BAT and other organs influences systemic metabolic fluxes and endocrine networks and that would be a potential explanation for the bR10KO metabolic phenotype. In this regard, BAT is reported to secrete hormones (regulatory molecules) that impact systemic metabolism (Gunawardana et al, 2012;Payab et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Blunting of insulin-stimulated glucose uptake in brown adipose tissue induces systemic metabolic dysregulation in female mice

Picatoste

Yammine

Leahey

et al. 2020

Preprint

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SummaryThe role of brown adipose tissue (BAT) in thermogenesis is widely appreciated, whereas its more recently described role in whole-body metabolism is not as well understood. Here we demonstrate that deletion of Rab10 from brown adipocytes reduces insulin-stimulated glucose transport by inhibiting translocation of the GLUT4 glucose transporter to the plasma membrane. This blunting of glucose uptake into brown adipocytes induces glucose intolerance and insulin-resistance in female but not male mice. The defect in glucose uptake does not affect the thermogenic function of BAT, and the dysregulation of whole-body metabolism is independent of the thermogenic function of BAT, thereby revealing a metabolism-specific role for BAT in female mice. The reduced glucose uptake induced by RAB10 deletion disrupts ChREBP regulation of the expression of de novo lipogenesis-related (DNL) genes, providing a link between DNL in BAT and whole-body metabolic regulation that is independent of thermogenesis.

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“…Obesity is the result of overconsumption of nutrients and a sedentary lifestyle. As the consumption of nutrients increases, an imbalance is created between energy intake and expenditure, leading to fat accumulation in adipose tissue (AT) and obesity [ 4 ]. The World Health Organization (WHO) estimates the number of obese people globally at 650 million [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Increasing energy expenditure and subsequent weight loss is a smart way to control and prevent obesity [ 7 ]. In this regard, although authoritative articles have approved anti-obesity drugs, such as orlistat, and the use of weight-loss surgeries, the use of these methods is associated with many side effects [ 4 ]. Health researchers have identified diet, especially antioxidant supplements, as the most appropriate treatment for obesity [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A Brief Overview of Oxidative Stress in Adipose Tissue with a Therapeutic Approach to Taking Antioxidant Supplements

Taherkhani

Ruhee

2021

Antioxidants

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One of the leading causes of obesity associated with oxidative stress (OS) is excessive consumption of nutrients, especially fast-foods, and a sedentary lifestyle, characterized by the ample accumulation of lipid in adipose tissue (AT). When the body needs energy, the lipid is broken down into glycerol (G) and free fatty acids (FFA) during the lipolysis process and transferred to various tissues in the body. Materials secreted from AT, especially adipocytokines (interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α)) and reactive oxygen species (ROS), are impressive in causing inflammation and OS of AT. There are several ways to improve obesity, but researchers have highly regarded the use of antioxidant supplements due to their neutralizing properties in removing ROS. In this review, we have examined the AT response to OS to antioxidant supplements focusing on animal studies. The results are inconsistent due to differences in the study duration and diversity in animals (strain, age, and sex). Therefore, there is a need for different studies, especially in humans.

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Brown adipose tissue transplantation as a novel alternative to obesity treatment: a systematic review

Cited by 41 publications

References 39 publications

Dietary low ratio of n‐6/n‐3 polyunsaturated fatty acids improve type 2 diabetes mellitus via activating brown adipose tissue in male mice

Dietary low ratio of n‐6/n‐3 polyunsaturated fatty acids improve type 2 diabetes mellitus via activating brown adipose tissue in male mice

Blunting of insulin-stimulated glucose uptake in brown adipose tissue induces systemic metabolic dysregulation in female mice

A Brief Overview of Oxidative Stress in Adipose Tissue with a Therapeutic Approach to Taking Antioxidant Supplements

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