Brown-McLean Syndrome in a Patient with Hallermann-Streiff Syndrome

Hallermann-Streiff syndrome diagnosed in the seventh decade of life

“…Previously reported patients with HSS were all infants, 5 , 6 children, 2 , 7 , 8 , 9 or at the oldest, young adolescents. 10 , 11 Thus, the current patient with HSS, first diagnosed in the seventh decade of life, is unique in the literature. Previously, HSS was reported over two or three generations, 15 , 16 while the current case seemed sporadic.…”

“… 7 The Brown-McLean syndrome is another corneal pathology characterized by peripheral corneal edema involving the stroma and epithelium. 10 Thus, corneal calcifications in eyes with/without a previous cataract surgery is unique in the literature. The mention of ocular injections administered several times might have been a steroid injection for iridocyclitis; thus, the chronic inflammation was likely to be associated with the corneal opacity in the current case.…”

“… 3 , 4 Most patients with HSS were recognized as having a congenital anomaly as a newborn or early in life because of the characteristic facial appearance, severe visual disturbance, and/or upper airway obstruction. 2 , 5 , 6 , 7 , 8 , 9 , 10 , 11 We report a case of HSS that was first recognized when the patient was in her seventh decade of life.…”

Brown-Mclean syndrome in an aphakic patient with homocystinuria

“…Other possible predisposing factors include chronic uveitis and iridodonesis in aphakic patients that may cause intermittent abrasion of the corneal endothelium leading to peripheral corneal edema. [ 1 4 6 7 8 9 ]…”

“…In addition, it has been documented in patients with no previous ocular surgery, including in patients with spontaneous lens resorption with iridodonesis, lens subluxation or luxation, the phakic eye with intermittent angle-closure, keratoconus, and myotonic dystrophy. [ 1 2 3 4 5 ]…”